Apollon Antibody (4): sc-136214
- Apollon Antibody (4) is a mouse monoclonal IgG1 provided at 50 µg/0.5 ml
- raised against amino acids 372-571 of Apollon of mouse origin
- recommended for detection of Apollon of mouse, rat, human and canine origin by WB and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Apollon Antibody (4). This work is in progress.
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SEE ALSO...
Apollon Antibody (4) is a mouse monoclonal IgG1 antibody that detects Apollon in mouse, rat, human, and canine samples through applications such as western blotting (WB) and immunofluorescence (IF). Apollon, also known as BRUCE or baculoviral IAP repeat-containing protein 6 (BIRC6), is a crucial member of the inhibitor of apoptosis protein (IAP) family, characterized by its baculovirus IAP repeat (BIR) domains, which play a significant role in inhibiting apoptosis. This large protein is primarily located in the Golgi apparatus, where Apollon is involved in the regulation of cellular processes, including the ubiquitination and proteasomal degradation of key apoptotic factors such as second mitochondria-derived activator of caspase (Smac) and caspase-9. The Golgi localization of Apollon is particularly important as this positioning allows for the modulation of protein trafficking and degradation pathways, which can influence cell survival and proliferation. Notably, Apollon has been implicated in tumorigenesis and the development of drug resistance in various brain cancer cell lines, highlighting Apollon′s potential as a therapeutic target in cancer treatment. Anti-Apollon antibody (4) provides a valuable tool for researchers investigating the mechanisms of apoptosis and the role of IAPs in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apollon Antibody (4) | sc-136214 | 50 µg/0.5 ml | $322.00 |