APOBEC1 Antibody (E-2): sc-166508

APOBEC1 Antibody (E-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects APOBEC1 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-APOBEC1 antibody (E-2) is available as non-conjugated format. APOBEC1 plays a crucial role in post-transcriptional editing of apolipoprotein B (apoB) mRNA, a process essential for maintaining proper balance of edited and unedited RNA molecules in hepatic cells. This editing is vital for producing functional apoB proteins, which are key components in lipid metabolism and transport. APOBEC1 is predominantly expressed in adult small intestine, but also found in stomach, colon, and testis, highlighting importance in various tissues. Structurally, APOBEC1 exists as a dimer and features conserved histidine and cysteine residues that form a zinc-binding motif, a characteristic shared with other cytidine deaminases. This structural similarity suggests APOBEC1 may have additional roles in RNA metabolism beyond functioning as an apoB RNA-specific cytidine deaminase. APOBEC1′s ability to interact with other proteins involved in RNA processing further underscores significance in cellular function and regulation.

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APOBEC1 Antibody (E-2) References:

1. An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: binding of Apobec-1 to this motif in the 3' untranslated region of c-myc increases mRNA stability.  |  Anant, S. and Davidson, NO. 2000. Mol Cell Biol. 20: 1982-92. PMID: 10688645
2. Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1.  |  Yang, Y., et al. 2000. J Biol Chem. 275: 22663-9. PMID: 10833526
3. Dimeric structure of a human apolipoprotein B mRNA editing protein and cloning and chromosomal localization of its gene.  |  Lau, PP., et al. 1994. Proc Natl Acad Sci U S A. 91: 8522-6. PMID: 8078915
4. Molecular cloning of a human small intestinal apolipoprotein B mRNA editing protein.  |  Hadjiagapiou, C., et al. 1994. Nucleic Acids Res. 22: 1874-9. PMID: 8208612
5. Human apolipoprotein B RNA editing deaminase gene (APOBEC1).  |  Fujino, T., et al. 1998. Genomics. 47: 266-75. PMID: 9479499

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-APOBEC1 Antibody (E-2) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-APOBEC1 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

APOBEC1 Antibody (E-2) Specifications

Alternate Product Name: APOBEC1

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 2-16

Epitope Target: APOBEC1

Epitope Species: mouse

Product Reactivity/Detection: APOBEC1

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for APOBEC1 Antibody (E-2): P: Blocking Peptide