apoA-II Antibody (ZZ6): sc-101261

apoA-II Antibody (ZZ6) is a mouse monoclonal IgG1 kappa light chain antibody that detects human apoA-II by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-apoA-II antibody (ZZ6) is available as a non-conjugated format. Apolipoprotein A-II plays a crucial role in lipid metabolism and is the second most abundant protein component of high-density lipoprotein (HDL) particles, where apoA-II significantly influences plasma levels of free fatty acids (FFA). apoA-II is vital for maintaining lipid homeostasis, as apoA-II helps regulate the metabolism of triglycerides and cholesterol, thereby contributing to cardiovascular health. Additionally, apoA-II is involved in the activation of lecithin cholesterol acyltransferase (LCAT), an enzyme essential for the formation of cholesteryl esters in plasma, which are important for the transport and storage of cholesterol. apoA-II′s ability to modulate lipid levels underscores apoA-II′s importance in preventing atherosclerosis and other lipid-related disorders, making apoA-II a valuable target for research and therapeutic interventions.

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apoA-II Antibody (ZZ6) References:

1. Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins.  |  Qin, S., et al. 2000. J Lipid Res. 41: 269-76. PMID: 10681411
2. Human ApoA-IV overexpression in transgenic mice induces cAMP-stimulated cholesterol efflux from J774 macrophages to whole serum.  |  Fournier, N., et al. 2000. Arterioscler Thromb Vasc Biol. 20: 1283-92. PMID: 10807744
3. GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex.  |  Deeg, MA., et al. 2001. J Lipid Res. 42: 442-51. PMID: 11254757
4. Butyrate stimulates ApoA-IV-containing lipoprotein secretion in differentiated Caco-2 cells: role in cholesterol efflux.  |  Nazih, H., et al. J Cell Biochem. 83: 230-8. PMID: 11573240
5. Role of apoA-II in lipid metabolism and atherosclerosis: advances in the study of an enigmatic protein.  |  Blanco-Vaca, F., et al. 2001. J Lipid Res. 42: 1727-39. PMID: 11714842
6. Increased plasma apoA-IV level is a marker of abnormal postprandial lipemia: a study in normoponderal and obese subjects.  |  Vergès, B., et al. 2001. J Lipid Res. 42: 2021-9. PMID: 11734575
7. Plasma distribution of apoA-IV in patients with coronary artery disease and healthy controls.  |  Ezeh, B., et al. 2003. J Lipid Res. 44: 1523-9. PMID: 12777472
8. apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB.  |  Gallagher, JW., et al. 2004. J Lipid Res. 45: 1826-34. PMID: 15258202
9. Response of ApoA-IV in pigs to long-term increased dietary oil intake and to the degree of unsaturation of the fatty acids.  |  Navarro, MA., et al. 2004. Br J Nutr. 92: 763-9. PMID: 15533264
10. HDL-apoA-II Is Strongly Associated with 1-Year Mortality in Acute Heart Failure Patients.  |  Klobučar, I., et al. 2022. Biomedicines. 10: PMID: 35884971
11. Plasma lipoproteins: apolipoprotein structure and function.  |  Mahley, RW., et al. 1984. J Lipid Res. 25: 1277-94. PMID: 6099394
12. The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers.  |  Vergnes, L., et al. 1997. Biochim Biophys Acta. 1348: 299-310. PMID: 9366246

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-apoA-II Antibody (ZZ6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-apoA-II Antibody (ZZ6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

apoA-II Antibody (ZZ6) Specifications

Alternate Product Name: apoA-II

Product Clone Name: ZZ6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-101

Epitope Target: apoA-II

Epitope Species: human

Product Reactivity/Detection: apoA-II

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for apoA-II Antibody (ZZ6): N/A