Apixaban-13C, d3 (CAS 1261393-15-0)
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Apixaban-13C, d3, is a labeled Apixaban (sc-364406). Apixaban-13C,d3 is deuterated and carbon-13 labeled. Apixaban is a direct, and selective antagonist of coagulation factor Xa. This variant of Apixaban distinguishes itself by the incorporation of isotopic labels, enhancing its utility in molecular research, particularly in the study of metabolic pathways and the dynamics of coagulation processes. By targeting factor Xa, a pivotal enzyme in the coagulation cascade responsible for the transformation of prothrombin into thrombin, Apixaban-13C, d3 acts to impede this enzymatic activity. The incorporation of isotopes allows for detailed tracing and analysis of the compound in biological systems, using techniques such as mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. These techniques can distinguish the labeled apixaban from its unlabeled form based on the mass difference contributed by the heavier isotopes.
Apixaban-13C, d3 (CAS 1261393-15-0) References
- A universal anti-Xa assay for rivaroxaban, apixaban, and edoxaban measurements: method validation, diagnostic accuracy and external validation. | Willekens, G., et al. 2021. Br J Haematol. 193: 1203-1212. PMID: 33954979
- Development and validation of an analytical method for the determination of direct oral anticoagulants (DOAC) and the direct thrombin-inhibitor argatroban by HPLC-MS/MS. | Brückner, L., et al. 2022. J Thromb Thrombolysis. 53: 777-787. PMID: 34762222
- Point-of-Care Assessment of Direct Oral Anticoagulation in Acute Ischemic Stroke: Protocol for a Prospective Observational Diagnostic Accuracy Study. | Sedghi, A., et al. 2022. Thromb Haemost. 122: 1954-1962. PMID: 35672013
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apixaban-13C, d3, 2.5 mg | sc-480057 | 2.5 mg | $340.00 |