Molecular structure of Apilimod, CAS Number: 541550-19-0
Apilimod (CAS 541550-19-0)
See product citations (5)
Alternate Names:
Apilimod also known as 3-Methylbenzaldehyde 2-[6-(4-Morpholinyl)-2-[2-(2-pyridinyl)ethoxy]-4- pyrimidinyl]hydrazone
Application:
Apilimod is a potent inhibitor of cytokines IL-12 and IL-23 production which are potential regulators of certain autoimmune and inflammatory diseases
CAS Number:
541550-19-0
Purity:
≥98%
Molecular Weight:
418.49
Molecular Formula:
C23H26N6O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Apilimod is a compound extensively studied in the field of immunology for its role as an inhibitor of the production of interleukin-12 (IL-12) and interleukin-23 (IL-23), cytokines involved in the regulation of immune responses. In cellular biology research, apilimod is utilized to explore the signaling pathways and the intracellular mechanisms that control cytokine production within immune cells, such as dendritic cells and macrophages. This compound has also been the subject of investigations into the endosomal trafficking pathways, owing to its ability to inhibit the PIKfyve kinase, which is a key regulator of vesicular trafficking. Researchers are interested in understanding the broader implications of PIKfyve inhibition by apilimod on cellular processes such as autophagy and endocytosis.
Apilimod (CAS 541550-19-0) References
- Drug evaluation: apilimod, an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency. | Billich, A. 2007. IDrugs. 10: 53-9. PMID: 17187316
- PIKfyve inhibition increases exosome release and induces secretory autophagy. | Hessvik, NP., et al. 2016. Cell Mol Life Sci. 73: 4717-4737. PMID: 27438886
- Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma. | Gayle, S., et al. 2017. Blood. 129: 1768-1778. PMID: 28104689
- The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection. | Nelson, EA., et al. 2017. PLoS Negl Trop Dis. 11: e0005540. PMID: 28403145
- Apilimod, a candidate anticancer therapeutic, arrests not only PtdIns(3,5)P2 but also PtdIns5P synthesis by PIKfyve and induces bafilomycin A1-reversible aberrant endomembrane dilation. | Sbrissa, D., et al. 2018. PLoS One. 13: e0204532. PMID: 30240452
- Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing. | Riva, L., et al. 2020. Nature. 586: 113-119. PMID: 32707573
- The PIKfyve Inhibitor Apilimod: A Double-Edged Sword against COVID-19. | Baranov, MV., et al. 2020. Cells. 10: PMID: 33375410
- Low rotational barriers for the most dynamically active methyl groups in the proposed antiviral drugs for treatment of SARS-CoV-2, apilimod and tetrandrine. | Mamontov, E., et al. 2021. Chem Phys Lett. 777: 138727. PMID: 33994552
- Apilimod alters TGFβ signaling pathway and prevents cardiac fibrotic remodeling. | Cinato, M., et al. 2021. Theranostics. 11: 6491-6506. PMID: 33995670
- Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease. | Kreutzberger, AJB., et al. 2021. bioRxiv.. PMID: 34100014
- ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. | Bowles, KR., et al. 2021. Cell. 184: 4547-4563.e17. PMID: 34314701
- Identification of potential COVID-19 treatment compounds which inhibit SARS Cov2 prototypic, Delta and Omicron variant infection. | Kumar, P., et al. 2022. Virology. 572: 64-71. PMID: 35598394
- Apilimod enhances specific productivity in recombinant CHO cells through cell cycle arrest and mediation of autophagy. | Lu, JT., et al. 2023. Biotechnol J. 18: e2200147. PMID: 36478399
Inhibitor of:
Angiogenesis, ARA160, ATP6V0E1, CHMP4B, FKF1, IL-17R, IL-17RC, IL-17REL, IL-23, ISG20, MTMR15, Ndfip2, PI 3-kinase C2y, PIP2, RUFY1, Sorting Nexin (SNX), TMEM55B, Type II 5-phosphatase, V1RC19, and VAC14.Activator of:
Coronavirus nucleocapsid, EVT-2, MTMR2, MVB12A, Tmsbl1, and V-ATPase C1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apilimod, 100 mg | sc-480051 | 100 mg | $428.00 | |||
Apilimod, 1 g | sc-480051A | 1 g | $2652.00 |