Apelin-13 trifluoroacetate salt
Application:
Apelin-13 trifluoroacetate salt is an endogenous ligand of G-protein coupled receptor APJ
Molecular Weight:
1663.84
Molecular Formula:
C69H111N23O16S•C2F3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Apelin-13 trifluoroacetate salt is the TFA salt of the 13 amino acid polypeptide encoded by the apelin gene which yields a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids (apelin-36, apelin-17, and apelin-13, respectively). Apelin-13 is an endogenous ligand of APLNR (APJ receptor), a G protein-coupled receptor (EC50 = 370 μM), that plays important roles in regulating fluid homeostasis, cardiovascular function, and insulin sensitivity. Research has also shown that Apelin-36 blocks the entry of human immunodeficiency virus into cells.
Apelin-13 trifluoroacetate salt References
- Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum. | Habata, Y., et al. 1999. Biochim Biophys Acta. 1452: 25-35. PMID: 10525157
- Characterization of apelin, the ligand for the APJ receptor. | Lee, DK., et al. 2000. J Neurochem. 74: 34-41. PMID: 10617103
- Apelin peptides block the entry of human immunodeficiency virus (HIV). | Zou, MX., et al. 2000. FEBS Lett. 473: 15-8. PMID: 10802050
- Emerging roles of apelin in biology and medicine. | Kleinz, MJ. and Davenport, AP. 2005. Pharmacol Ther. 107: 198-211. PMID: 15907343
- High-fat diet and chronic stress reduce central pressor and tachycardic effects of apelin in Sprague-Dawley rats. | Cudnoch-Jedrzejewska, A., et al. 2015. Clin Exp Pharmacol Physiol. 42: 52-62. PMID: 25311903
- Effects of Apelin on RAW264.7 cells under both normal and hypoxic conditions. | Yang, F., et al. 2015. Peptides. 69: 133-43. PMID: 25963277
- Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation. | Zou, Y., et al. 2016. Neurochem Res. 41: 1635-44. PMID: 26961889
- The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet. | Czarzasta, K., et al. 2016. Clin Exp Pharmacol Physiol. 43: 983-94. PMID: 27378063
- The flavonoid quercetin decreases ACE2 and TMPRSS2 expression but not SARS-CoV-2 infection in cultured human lung cells. | Houghton, MJ., et al. 2024. Biofactors.. PMID: 38886986
- Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. | Tatemoto, K., et al. 1998. Biochem Biophys Res Commun. 251: 471-6. PMID: 9792798
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Apelin-13 trifluoroacetate salt, 1 mg | sc-319826 | 1 mg | $250.00 |