APC 366 CAS: 158921-85-8
MF: C22H28N6O4
APC 366 is a elective inhibitor of the mast cell tryptase.

APC 366 (CAS 158921-85-8)

APC 366 | CAS 158921-85-8 is rated 5.0 out of 5 by 1.
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Alternate Names: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Application: APC 366 is a elective inhibitor of the mast cell tryptase
CAS Number: 158921-85-8
Purity: ≥96%
Molecular Weight: 440.49
Molecular Formula: C22H28N6O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Selective inhibitor of the mast cell tryptase (Ki = 7.1 µM) that inhibits tryptase-induced histamine release from human tonsil and lung cells.


References

1. Numerof, R.P., et al. 1997. Exp. Opin. Invest. Drugs. 6: 811-817. PMID: 15989643
2. He. S., et al. 1998. J. Pharmacol. Exp. Ther. 286: 289-297. PMID: 9655871
3. Barrios, V.E., et al. 1998. Life Sci. 63: 2295-2303. PMID: 9877219
4. He, S., et al. 2004. J. Pharmacol. Exp. Ther. 309: 119-126. PMID: 14722328

Formulation :
TFA salt
Physical State :
Solid
Solubility :
Soluble in 20% acetonitrile (1 mg/ml).
Storage :
Store at -20° C
Melting Point :
331.47° C (Predicted)
Boiling Point :
754.49° C (Predicted)
Density :
~1.5 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
Ki Data :
mast cell tryptase: Ki= 7.1 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
177340
MDL Number :
MFCD09971084
SMILES :
C1C[[email protected]](N(C1)C(=O)[[email protected]](CCCN=C(N)N)NC(=O)C2=C(C3=CC=CC=C3C=C2)O)C(=O)N

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Certificate of Analysis

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APC 366 (CAS 158921-85-8) Product Citations

See how others have used APC 366 (CAS 158921-85-8). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 32366312  J Neuroinflammation. 17: 144.

PMID: # 30825834  Cytokine. 117: 50-58.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from He et al He et al. (PubMed ID 14722328) found that the tryptase inhibitor APC366 significantly inhibited histamine release stimulated by anti-IgE or calcium ionophore from enzymatically dispersed human lung cells. -SCBT Publication Review
Date published: 2015-06-29
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