APBA2BP Antibody (A-2): sc-376656

APBA2BP Antibody (A-2) is a mouse monoclonal IgG3 kappa light chain antibody that detects APBA2BP protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-APBA2BP antibody (A-2) is available as a non-conjugated antibody. APBA2BP protein, also known as beta-Amyloid A4 protein-binding family A member 2-binding protein, NECAB3, NIP1, SYTIP2, or XB51, is a 396 amino acid protein primarily localized to the perinuclear region of the cytoplasm. Such localization positions APBA2BP to effectively interact with key proteins involved in amyloid processing, particularly the β-Amyloid precursor protein. APBA2BP contains one calcium-binding EF-hand domain and one ABM domain, essential for modulating calcium signaling and protein interactions. APBA2BP shows high expression in skeletal muscle and heart, with lower levels in the pancreas and brain, playing a significant role in regulating mature β-Amyloid formation through X11β interaction, thereby influencing Alzheimer′s disease pathogenesis. Three isoforms of APBA2BP arise from alternative splicing, contributing to functional diversity and regulatory mechanisms in various tissues.

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APBA2BP Antibody (A-2) References:

1. Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins.  |  Sugita, S. and Südhof, TC. 2000. Biochemistry. 39: 2940-9. PMID: 10715114
2. Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein.  |  Lee, DS., et al. 2000. J Biol Chem. 275: 23134-8. PMID: 10833507
3. NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.  |  Sugita, S., et al. 2002. Neuroscience. 112: 51-63. PMID: 12044471
4. XB51 isoforms mediate Alzheimer's beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms.  |  Sumioka, A., et al. 2003. Biochem J. 374: 261-8. PMID: 12780348
5. NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.  |  Yoo, JC., et al. 2004. Exp Cell Res. 292: 393-402. PMID: 14697346
6. EFCBP1/NECAB1, a brain-specifically expressed gene with highest abundance in temporal lobe, encodes a protein containing EF-hand and antibiotic biosynthesis monooxygenase domains.  |  Wu, H., et al. 2007. DNA Seq. 18: 73-9. PMID: 17364817
7. A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library.  |  Büssow, K., et al. 1998. Nucleic Acids Res. 26: 5007-8. PMID: 9776767

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-APBA2BP Antibody (A-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-APBA2BP Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

APBA2BP Antibody (A-2) Specifications

Alternate Product Name: APBA2BP

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 67-101

Epitope Target: APBA2BP

Epitope Species: human

Product Reactivity/Detection: APBA2BP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for APBA2BP Antibody (A-2): P: Blocking Peptide