AP5S1 Antibody (E-4): sc-514823

AP5S1 Antibody (E-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP5S1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AP5S1 (E-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AP5S1, also known as C20orf29, consists of 200 amino acids and is a crucial component of the adaptor protein complex 5 (AP-5), which plays a significant role in intracellular transport by sorting cargo into vesicles for delivery between different membrane compartments. This sorting mechanism is particularly important for endosomal trafficking, which is essential for maintaining cellular homeostasis and facilitating communication between organelles. AP5S1 is located on chromosome 20p13, a region that encompasses approximately 63 million bases and 600 genes, some of which are implicated in various diseases, including amyotrophic lateral sclerosis and spongiform encephalopathies. AP5S1′s presence in the AP-5 complex highlights its potential as a target for therapeutic interventions aimed at modulating vesicular transport processes, making AP5S1 a valuable tool for researchers studying cellular dynamics and disease mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

AP5S1 Antibody (E-4) References:

1. Does PRNP gene control the clinical and pathological phenotype of human spongiform transmissible encephalopathies?  |  Masullo, C. and Macchi, G. 2001. Clin Neuropathol. 20: 19-25. PMID: 11220690
2. Gerstmann-Sträussler-Scheinker syndrome,fatal familial insomnia, and kuru: a review of these less common human transmissible spongiform encephalopathies.  |  Collins, S., et al. 2001. J Clin Neurosci. 8: 387-97. PMID: 11535002
3. Early pattern of epilepsy in the ring chromosome 20 syndrome.  |  Ville, D., et al. 2006. Epilepsia. 47: 543-9. PMID: 16529619
4. Trisomy 20 mosaicism and nonmosaic trisomy 20: a report of 2 cases.  |  Joó, JG., et al. 2006. J Reprod Med. 51: 209-12. PMID: 16674019
5. A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis.  |  Lundwall, A. 2007. Asian J Androl. 9: 540-4. PMID: 17589793
6. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.  |  Słabicki, M., et al. 2010. PLoS Biol. 8: e1000408. PMID: 20613862
7. The fifth adaptor protein complex.  |  Hirst, J., et al. 2011. PLoS Biol. 9: e1001170. PMID: 22022230
8. The prion diseases.  |  Prusiner, SB. 1998. Brain Pathol. 8: 499-513. PMID: 9669700

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AP5S1 Antibody (E-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-AP5S1 Antibody (E-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AP5S1 Antibody (E-4) Specifications

Alternate Product Name: AP5S1

Product Clone Name: E-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 32-53

Epitope Target: AP5S1

Epitope Species: human

Product Reactivity/Detection: AP5S1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for AP5S1 Antibody (E-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin