AOI 987 (CAS 846022-21-7)
CAS Number:
846022-21-7
Molecular Weight:
411.16
Molecular Formula:
C18H18N3O3BF4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
AOI 987 is a fluorescent dye specifically designed for near-infrared (near-IR) imaging. AOI-987 is a member of the oxazine class of dyes, characterized by a potent combination of high lipophilicity and low molecular weight (427 Da). It exhibits the ability to effectively cross the blood-brain barrier, enabling its interaction with amyloid plaques. AOI 987 binds to amyloid plaques. Through contrast discrimination, the employment of AOI-987 vouches for a major step ahead in organelle diagnostics.
AOI 987 (CAS 846022-21-7) References
- Design, synthesis, and testing of difluoroboron-derivatized curcumins as near-infrared probes for in vivo detection of amyloid-beta deposits. | Ran, C., et al. 2009. J Am Chem Soc. 131: 15257-61. PMID: 19807070
- BODIPY-based molecular probe for imaging of cerebral β-amyloid plaques. | Ono, M., et al. 2012. ACS Chem Neurosci. 3: 319-24. PMID: 22860198
- Molecular imaging of β-amyloid plaques with near-infrared boron dipyrromethane (BODIPY)-based fluorescent probes. | Watanabe, H., et al. 2013. Mol Imaging. 12: 338-47. PMID: 23759374
- Past and recent progress of molecular imaging probes for β-amyloid plaques in the brain. | Cui, M. 2014. Curr Med Chem. 21: 82-112. PMID: 23992340
- Dual Functional Small Molecule Probes as Fluorophore and Ligand for Misfolding Proteins. | Zhang, X. and Ran, C. 2013. Curr Org Chem. 17: PMID: 24363605
- Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience. | Staderini, M., et al. 2015. Chem Soc Rev. 44: 1807-19. PMID: 25622714
- Development of Phenothiazine-Based Theranostic Compounds That Act Both as Inhibitors of β-Amyloid Aggregation and as Imaging Probes for Amyloid Plaques in Alzheimer's Disease. | Dao, P., et al. 2017. ACS Chem Neurosci. 8: 798-806. PMID: 28097868
- Smart D-π-A Type Near-Infrared Aβ Probes: Effects of a Marked π Bridge on Optical and Biological Properties. | Zhou, K., et al. 2017. Anal Chem. 89: 9432-9437. PMID: 28758731
- Fluorescent Imaging of β-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe. | Ren, W., et al. 2018. Bioconjug Chem. 29: 3459-3466. PMID: 30189724
- Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules. | Jun, YW., et al. 2019. ACS Cent Sci. 5: 209-217. PMID: 30834309
- Advances in Optoacoustic Neurotomography of Animal Models. | Ovsepian, SV., et al. 2019. Trends Biotechnol. 37: 1315-1326. PMID: 31662189
- Versatile fluorescent probes for near-infrared imaging of amyloid-β species in Alzheimer's disease mouse model. | Peng, C., et al. 2019. J Mater Chem B. 7: 1986-1995. PMID: 32254802
- Ultrasmall T1-T2 Magnetic Resonance Multimodal Imaging Nanoprobes for the Detection of β-amyloid Aggregates in Alzheimer's Disease Mice. | Cai, J., et al. 2020. ACS Appl Mater Interfaces. 12: 26812-26821. PMID: 32427456
- Potential Alzheimer's disease therapeutic nano-platform: Discovery of amyloid-beta plaque disaggregating agent and brain-targeted delivery system using porous silicon nanoparticles. | Kim, J., et al. 2023. Bioact Mater. 24: 497-506. PMID: 36685808
- Vanillin Benzothiazole Derivative Reduces Cellular Reactive Oxygen Species and Detects Amyloid Fibrillar Aggregates in Alzheimer's Disease Brain. | Gharai, PK., et al. 2023. ACS Chem Neurosci. 14: 773-786. PMID: 36728363
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AOI 987, 5 mg | sc-481117 | 5 mg | $425.00 |