Antipain (CAS 37691-11-5)
See product citations (1)
QUICK LINKS
Antipain is a reversible inhibitor of Ser and Cys proteases with an activity spectrum comparable to leupeptin that was originally isolated from various strains of actinomycetes. H-1765 inhibited transformation of NIH3T3 cells after transfection with an activated H-ras oncogene. Antipain has been employed for evaluating the role of proteases in the process of malignant transformation of BALB/c 3T3 cells. Early studies investigated the potential for Antipain to alter DNA damage and chromosomal aberrations in irradiated cells or those treated with chemical mutagens such as N-methyl-N′-nitro-N-nitrosoguanidine (MNNG). Antipain was used in 2010 to obtain a crystal structure of the Leishmania major oligopeptidase B (OPB), a serine protease that serves as a virulence factor in trypanosomatids. The binding of Antipain to OPB has been used in molecular dynamic studies to identify other OPB inhibitors.
Antipain (CAS 37691-11-5) References
- Antipain-induced suppression of oncogene expression in H-ras-transformed NIH3T3 cells. | Cox, LR., et al. 1991. Cancer Res. 51: 4810-4. PMID: 1893373
- c-fos mRNA levels are reduced in the presence of antipain and Bowman-Birk inhibitor. | Caggana, M. and Kennedy, AR. 1989. Carcinogenesis. 10: 2145-8. PMID: 2509094
- Inhibition of fibrinogen receptor expression and serotonin release by leupeptin and antipain. | Baldassare, JJ., et al. 1985. J Biol Chem. 260: 10531-5. PMID: 2993278
- The protease inhibitor antipain has a beneficial synergistic effect with trehalose for ram semen cryopreservation. | Akhtarshenas, B., et al. 2018. Reprod Domest Anim. 53: 1359-1366. PMID: 30011087
- Suppression of the radiation-induced expression of a tumor-associated antigen in human cell hybrids by the protease inhibitor antipain. | Sun, C., et al. 1988. Carcinogenesis. 9: 2333-5. PMID: 3191580
- Antipain-mediated suppression of sister chromatid exchanges induced by an inhibitor of poly (ADP-ribose) polymerase. | Schwartz, JL. and Weichselbaum, RR. 1985. Environ Mutagen. 7: 703-9. PMID: 3930238
- Role of cellular proteinases in acute myocardial infarction. I. Proteolysis in nonischemic and ischemic rat myocardium and the effects of antipain, leupeptin, pepstatin and chymostatin administered in vivo. | Bolli, R., et al. 1983. J Am Coll Cardiol. 2: 671-80. PMID: 6350399
- Protease inhibitor antipain suppresses 12-O-tetradecanoyl-phorbol-13-acetate induction of plasminogen activator in transformable mouse embryo fibroblasts. | Long, SD., et al. 1981. Carcinogenesis. 2: 933-6. PMID: 6794928
- Antipain inhibits N-methyl-N'-nitro-N-nitrosoguanidine-induced transformation and increases chromosomal aberrations. | DiPaolo, JA., et al. 1980. Proc Natl Acad Sci U S A. 77: 6649-53. PMID: 6935676
- Cytotoxic effects of protease inhibitors on human cells. 1. High sensitivity of xeroderma pigmentosum cells to antipain. | Ishizaki, K., et al. 1980. Cancer Lett. 10: 199-205. PMID: 7000335
- Differential antimutagenic effects of caffeine and the protease inhibitor antipain on mutagenesis by various mutagens in Escherichia coli. | Ichikawa-Ryo, H. and Kondo, S. 1980. Mutat Res. 72: 311-22. PMID: 7003368
- Antipain, but not cycloheximide, suppresses radiation transformation when present for only one day at five days post-irradiation. | Kennedy, AR. 1982. Carcinogenesis. 3: 1093-5. PMID: 7139867
- Antipain and 12-O-tetradecanoyl-phorbol-13-acetate: phenomenology of effects on UV mutagenesis in V79 Chinese hamster cells. | Fujiwara, Y. and Tatsumi, M. 1980. Mutat Res. 73: 183-93. PMID: 7254217
- Antipain and radiation effects on oncogenic transformation and sister chromatid exchanges in Syrian hamster embryo and mouse C3H/10T1/2 cells. | Geard, CR., et al. 1981. Carcinogenesis. 2: 1229-33. PMID: 7326822
- Involvement of antipain-sensitive protease activity in the interferon-beta-induced UV-refractoriness of Cockayne syndrome fibroblasts. | Sugita, K., et al. 1996. Mutat Res. 357: 177-81. PMID: 8876692
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antipain, 5 mg | sc-291906 | 5 mg | $117.00 | |||
Antipain, 25 mg | sc-291906A | 25 mg | $407.00 |