Molecular structure of Antimycin A3, CAS Number: 522-70-3
Antimycin A3 (CAS 522-70-3)
Alternate Names:
Blastmycin
Application:
Antimycin A3 is a potent inhibitor of respiration
CAS Number:
522-70-3
Molecular Weight:
520.57
Molecular Formula:
C26H36N2O9
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antimycin A3 is a homologue of the antimycin complex. It is a more polar analogue of A1 and A2 and is a potent inhibitor of respiration by inhibiting the oxidation of ubiquinol to ubiquinone. It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM. Antimycin A3 exhibits broad biological activity as an antifungal, anthelmintic, insecticidal, antiviral and antitumor active.
Antimycin A3 (CAS 522-70-3) References
- UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. IV. Comparative studies of UK-2A with antimycin A3 on cytotoxic activity and reactive oxygen species generation in LLC-PK1 cells. | Takimoto, H., et al. 1999. J Antibiot (Tokyo). 52: 480-4. PMID: 10480572
- Antimycin A mimics a cell-death-inducing Bcl-2 homology domain 3. | Tzung, SP., et al. 2001. Nat Cell Biol. 3: 183-91. PMID: 11175751
- UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. | Tani, K., et al. 2002. J Antibiot (Tokyo). 55: 315-21. PMID: 12014448
- Zinc is involved in the expression of a nuclear-encoded alternative oxidase gene in the yeast Hansenula anomala. | Minagawa, N., et al. 2002. Biosci Biotechnol Biochem. 66: 2645-50. PMID: 12596861
- Growth inhibition dependent on reactive oxygen species generated by C9-UK-2A, a derivative of the antifungal antibiotic UK-2A, in Saccharomyces cerevisiae. | Fujita, K., et al. 2004. J Antibiot (Tokyo). 57: 511-7. PMID: 15515888
- UK-2A, B, C and D, novel antifungal antibiotics from streptomyces sp. 517-02 VI (3). Role of substituents on dilactone ring of UK-2A and antimycin A3 against generation of reactive oxygen species in porcine renal proximal tubule LLC-PK1 cells. | Fujita, K., et al. 2004. J Antibiot (Tokyo). 57: 687-90. PMID: 15638330
- Potentiation of fungicidal activities of trans-anethole against Saccharomyces cerevisiae under hypoxic conditions. | Fujita, K. and Kubo, I. 2004. J Biosci Bioeng. 98: 490-2. PMID: 16233742
- Inhibition of electron transport of rat liver mitochondria by unnatural (-)-antimycin A3. | Miyoshi, H., et al. 1991. FEBS Lett. 292: 61-3. PMID: 1959630
- Multiple BH3 mimetics antagonize antiapoptotic MCL1 protein by inducing the endoplasmic reticulum stress response and up-regulating BH3-only protein NOXA. | Albershardt, TC., et al. 2011. J Biol Chem. 286: 24882-95. PMID: 21628457
- Antimycin A-like molecules inhibit cyclic electron transport around photosystem I in ruptured chloroplasts. | Taira, Y., et al. 2013. FEBS Open Bio. 3: 406-10. PMID: 24251103
- Protocol to analyze bioenergetics in single human induced-pluripotent-stem-cell-derived kidney organoids using Seahorse XF96. | Miguel, V., et al. 2023. STAR Protoc. 4: 101999. PMID: 36607813
- A novel method of screening for immunomodulating substances, establishment of an assay system and its application to culture broths of microorganisms. | Nakamura, A., et al. 1986. J Antibiot (Tokyo). 39: 1148-54. PMID: 3759665
- The total synthesis of a diastereomeric mixture of antimycin A3 (blastmycin). | Kinoshita, M., et al. 1969. J Antibiot (Tokyo). 22: 580-2. PMID: 5364435
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antimycin A3, 1 mg | sc-391459 | 1 mg | $208.00 |