Antibiotic LL Z1640-4 CAS: 66018-41-5
MF: C19H24O7
MW: 364.39
A cis-enol resorcylic acid lactone exhibiting antiviral and antiprotozoan activity.

Antibiotic LL Z1640-4 (CAS 66018-41-5)

Antibiotic LL Z1640-4 | CAS 66018-41-5 is rated 5.0 out of 5 by 1.
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Application: Antibiotic LL Z1640-4 is a cis-enol resorcylic acid lactone exhibiting antiviral and antiprotozoan activity
CAS Number: 66018-41-5
Purity: >95%
Molecular Weight: 364.39
Molecular Formula: C19H24O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Antibiotic LL Z1640-4 is a cis-enol resorcylic acid lactone first reported in 1978 exhibiting both antiviral and antiprotozoan activity. More recently, antibiotic LL Z1640-2 (sc-202055) containing the essential cis-enone system that selectively inhibits TAK 1 has gained literature focus. With its inactive cis-enol, Antibiotic LL Z1640-4 is an ideal negative control to help dissect the selectivity of the MAP kinases.

Physical State :
Solid
Derived From :
Curvularis sp.
Solubility :
Soluble in ethanol, methanol, DMSO, and DMF. Limited water solubility.
Storage :
Store at -20° C
Boiling Point :
636.31° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = >50 µM; MCF7 (Breast carcinoma cells): IC50 = >100 µM (human); Nuclear factor NF-kappa-B p65 subunit: IC50 = >50 µM (human); HT-29 (Colon adenocarcinoma cells): IC50 = >25 µM (human); MDA-MB-435 (Breast metastasis of melanoma cells): IC50 = >25 µM (human)
pK Values :
pKa: 7.36
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46888372
SMILES :
CC1CC=CC(C(C(CC=CC2=CC(=CC(=C2C(=O)O1)O)OC)O)O)O

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Certificate of Analysis

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Antibiotic LL Z1640-4 (CAS 66018-41-5)  Product Citations

See how others have used Antibiotic LL Z1640-4 (CAS 66018-41-5). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 16978662  Sekiya, M. et al. 2006. Life Sci. 80: 113-119.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Various publications cite the use of Antibiotic Various publications cite the use of Antibiotic LL Z1640-4 as an negative control to help dissect the selectivity of the MAP kinases. -SCBT Publication Review
Date published: 2015-03-06
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