Molecular structure of Antalarmin hydrochloride, CAS Number: 220953-69-5
Antalarmin hydrochloride (CAS 220953-69-5)
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Application:
Antalarmin hydrochloride is a non-peptide CRF-RI receptor antagonist
CAS Number:
220953-69-5
Purity:
≥99%
Molecular Weight:
415.01
Molecular Formula:
C24H34N4.HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Antalarmin hydrochloride is a non-peptide CRF-RI (type 1 corticotropin-releasing factor; CR1) receptor antagonist. CRF-RI belongs to the family of CRF receptors, which are involved in modifying the autonomic, behavioral, and endocrine immune response to stress. Reports indicate that Antalarmin blocks ACTH release stimulated by CRH, and inflammation induced by carageenin. A structural analog of Antalarmin is CP 154526 (sc-205268). We supply the Antalarmin hydrochloride form.
Antalarmin hydrochloride (CAS 220953-69-5) References
- Recent advances with the CRF1 receptor: design of small molecule inhibitors, receptor subtypes and clinical indications. | McCarthy, JR., et al. 1999. Curr Pharm Des. 5: 289-315. PMID: 10213797
- Effects of antalarmin, a CRF type 1 receptor antagonist, on anxiety-like behavior and motor activation in the rat. | Zorrilla, EP., et al. 2002. Brain Res. 952: 188-99. PMID: 12376179
- Loss of cannabinoid receptor CB1 induces preterm birth. | Wang, H., et al. 2008. PLoS One. 3: e3320. PMID: 18833324
- Blockade of corticotropin-releasing hormone receptor 1 attenuates early-life stress-induced synaptic abnormalities in the neonatal hippocampus. | Liao, XM., et al. 2014. Hippocampus. 24: 528-40. PMID: 24493406
- Corticotropin-releasing hormone modulates airway vagal preganglionic neurons of Sprague-Dawley rats at multiple synaptic sites via activation of its type 1 receptors: Implications for stress-associated airway vagal excitation. | Guo, Y., et al. 2017. Neuroscience. 355: 101-112. PMID: 28499969
- The Central Amygdala Corticotropin-releasing hormone (CRH) Neurons Modulation of Anxiety-like Behavior and Hippocampus-dependent Memory in Mice. | Paretkar, T. and Dimitrov, E. 2018. Neuroscience. 390: 187-197. PMID: 30170157
- The effect of a corticotropin-releasing factor receptor 1 antagonist on the fear conditioning response in low- and high-anxiety rats after chronic corticosterone administration. | Skórzewska, A., et al. 2019. Stress. 22: 113-122. PMID: 30345859
- UCN2: a new candidate influencing pancreatic β-cell adaptations in pregnancy. | Simpson, SJS., et al. 2020. J Endocrinol. 245: 247-257. PMID: 32106091
- Downregulation of CRHBP is associated with trophoblast invasion inhibition in recurrent pregnancy loss. | Sun, F., et al. 2024. Reproduction. 167: PMID: 37947291
- In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation. | Webster, EL., et al. 1996. Endocrinology. 137: 5747-50. PMID: 8940412
Inhibitor of:
CRF-BP, CRF-RI, CRF-RII, CRFR, pro-MCH, urocortin (UCN), and urocortin III.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Antalarmin hydrochloride, 10 mg | sc-203820 | 10 mg | $186.00 | |||
Antalarmin hydrochloride, 50 mg | sc-203820A | 50 mg | $640.00 |