Ansatrienin A CAS: 82189-03-5
MF: C36H48N2O8
MW: 636.8
An ansamycin antibiotic inhibitor of osteoclastic bone resorption.

Ansatrienin A (CAS 82189-03-5)

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Application: An ansamycin antibiotic inhibitor of osteoclastic bone resorption
CAS Number: 82189-03-5
Molecular Weight: 636.8
Molecular Formula: C36H48N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Ansatrienin A is an ansamycin antibiotic originally isolataed from Streptomyces collinus. Known to potentiate the actions of some clinical anti-cancer agents as well as having been shown to inhibit osteoclastic bone resorption. Certain studies report its


References

1. Coronelli, C., et al. 1967. J. Antibiot. 20: 329-333. PMID: 5631366
2. Sugita, M., et al. 1982. J. Antibiot. 35: 1460-1466. PMID: 7161184
3. Sugita, M., et al. 1982. J. Antibiot. 35: 1467-1473. PMID: 7161185
4. Kuwano, M., et al. 1983. Gann. 74: 759-766. PMID: 6196249
5. Wu, T.S. 1987. J. Nat. Prod. 50: 108-118. PMID: 3598593
6. Feuerbach, D., et al. 1995. J. Biol. Chem. 270: 25949-25955. PMID: 7592784
7. Chen, S., et al. 1999. Eur. J. Biochem. 261: 98-107. PMID: 10103039
8. Patton, S.M., et al. 2000. Biochemistry. 39: 7595-7604. PMID: 10858310
9. Kawamura, T., et al. 2008. J. Antibiot. 61: 303-311. PMID: 18653996

Appearance :
Powder
Physical State :
Solid
Derived From :
Streptomyces</I>
Solubility :
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6440887
SMILES :
C[[email protected]@H]1[[email protected]](C/C=C/C=C/C=C/[[email protected]@H](CC(=O)NC2=CC(=O)C=C(C2=O)CC/C=C(/[[email protected]@ H]1O)\\C)OC)OC(=O)[[email protected]@H](C)NC(=O)C3CCCCC3

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Ansatrienin A  Product Citations

See how others have used Ansatrienin A. Click on the entry to view the PubMed entry .

Citations 1 to 8 of 8 total

PMID: # 18653996  Kawamura, T. et al. 2008. J. Antibiot. 61: 303-311.

PMID: # 10858310  Patton, SM. et al. 2000. Biochemistry. 39: 7595-7604.

PMID: # 10103039  Chen, S. et al. 1999. Eur. J. Biochem. 261: 98-107.

PMID: # 7592784  Feuerbach, D. et al. 1995. J. Biol. Chem. 270: 25949-25955.

PMID: # 7161184  Sugita, M. et al. 1982. J. Antibiot. 35: 1460-1466.

PMID: # 7161185  Sugita, M. et al. 1982. J. Antibiot. 35: 1467-1473.

PMID: # 5631366  Coronelli, C. et al. 1967. J. Antibiot. 20: 329-333.

PMID: # 3598593  Wu, TS. et al. 1987 Jan-Feb. J. Nat. Prod. 50: 108-118.

Citations 1 to 8 of 8 total
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