ANKTM1 Antibody (C-4): sc-166469

ANKTM1 Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects ANKTM1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ANKTM1, also known as TRPA1, is a crucial ion channel that plays a significant role in sensory transduction, particularly in nociceptors and hair cells. ANKTM1 is primarily located in the plasma membrane of sensory neurons and inner ear hair cells, where ANKTM1 is essential for detecting environmental stimuli such as noxious cold temperatures and irritating compounds like garlic and mustard oil. ANKTM1 localization in these cells is vital because ANKTM1 allows for rapid response to potentially harmful stimuli, contributing to pain perception and mechanotransduction. Furthermore, ANKTM1 activation is linked to calcium influx, which is critical for various cellular signaling pathways. Understanding ANKTM1 function and location not only sheds light on ANKTM1′s role in sensory perception but also highlights ANKTM1′s potential as a therapeutic target for conditions like cold hyperalgesia, which can arise from inflammation and nerve damage.

The preferred ANKTM1 antibody is ANKTM1 Antibody (C-5): sc-376495.