Molecular structure of Anhydrovinblastine, CAS Number: 38390-45-3
Anhydrovinblastine (CAS 38390-45-3)
Alternate Names:
Vincaleukoblastine, 3′,4′-didehydro-4′-deoxy-
Application:
Anhydrovinblastine is an antimicrotubule
CAS Number:
38390-45-3
Purity:
≥98%
Molecular Weight:
792.96
Molecular Formula:
C46H56N4O8
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Anhydrovinblastine, derived from the alkaloid vinblastine. Anhydrovinblastine′s primary action is the disruption of microtubule dynamics, an essential component of the cellular cytoskeleton. Microtubules play a role in various cellular processes including cell division, maintenance of cell shape, and intracellular transport. Anhydrovinblastine binds to tubulin, the building block of microtubules, preventing their proper assembly and consequently leading to cell cycle arrest during the metaphase. This property of anhydrovinblastine is particularly valuable in studies focused on understanding the mechanisms of cell cycle regulation and mitotic inhibition. Overall, anhydrovinblastine is a critical compound in the realm of biochemical research, offering insights into the fundamental processes of cell division.
Anhydrovinblastine (CAS 38390-45-3) References
- Concise synthesis of anhydrovinblastine from leurosine. | Hardouin, C., et al. 2002. Org Lett. 4: 1151-3. PMID: 11922805
- Selective deoxygenation of leurosine: concise access to anhydrovinblastine. | Hardouin, C., et al. 2002. J Org Chem. 67: 6571-4. PMID: 12201787
- Phase I and pharmacokinetic study of anhydrovinblastine every 3 weeks in patients with refractory solid tumors. | Ramnath, N., et al. 2003. Cancer Chemother Pharmacol. 51: 227-30. PMID: 12655441
- Stereoselective conversion of anhydrovinblastine into vinblastine utilizing an anti-vinblastine monoclonal antibody as a chiral mould. | Shirahama, T., et al. 2006. Chem Pharm Bull (Tokyo). 54: 665-8. PMID: 16651762
- Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues. | Shao, Y., et al. 2007. Bioorg Med Chem. 15: 5061-75. PMID: 17544278
- Molecular cloning and characterization of a vacuolar class III peroxidase involved in the metabolism of anticancer alkaloids in Catharanthus roseus. | Costa, MM., et al. 2008. Plant Physiol. 146: 403-17. PMID: 18065566
- Direct coupling of catharanthine and vindoline to provide vinblastine: total synthesis of (+)- and ent-(-)-vinblastine. | Ishikawa, H., et al. 2008. J Am Chem Soc. 130: 420-1. PMID: 18081297
- Inhibitors of tubulin polymerization: synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III. | Passarella, D., et al. 2008. Bioorg Med Chem. 16: 6269-85. PMID: 18468444
- Total synthesis of (+)-vinblastine: control of the stereochemistry at C18'. | Yokoshima, S., et al. 2010. Chem Rec. 10: 101-18. PMID: 20394103
- On the elucidation of the mechanism of Vinca alkaloid fluorination in superacidic medium. | Giovanelli, E., et al. 2011. Org Lett. 13: 4116-9. PMID: 21732596
- Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogs. | Song, W., et al. 2012. Bioorg Med Chem Lett. 22: 387-90. PMID: 22115594
- A simple and rapid HPLC-DAD method for simultaneously monitoring the accumulation of alkaloids and precursors in different parts and different developmental stages of Catharanthus roseus plants. | Pan, Q., et al. 2016. J Chromatogr B Analyt Technol Biomed Life Sci. 1014: 10-6. PMID: 26854826
- Investigating distributions and changes of alkaloids in living Catharanthus roseus under low-phosphorus stress using wooden-tip electrospray ionisation mass spectrometry. | Wu, L., et al. 2020. Phytochem Anal. 31: 739-746. PMID: 32304155
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NCX2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Anhydrovinblastine, 25 mg | sc-358045 | 25 mg | $510.00 | |||
Anhydrovinblastine, 100 mg | sc-358045A | 100 mg | $1428.00 |