Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumor activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins.
1. Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. Hayakawa Y. et al. J. Antibiot. 1995, 48, 954. 2. New antitumor antibiotics, anguinomycins A and B. Hayakawa Y. et al. J. Antibiot. 1987, 40, 1349
Soluble in methanol, and ethanol. Insoluble in DMSO.
Store at -20° C
714.94° C at 760 mmHg (Predicted)
1.10 g/cm3 (Predicted)
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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What is the solubility limit in EtOH?
Asked by: toczy
Thank you for your question. Anguinomycin A is an oil rather than a solid and readily dissolves in most common solvents except water. We could not find any detailed solubility study. It should not be necessary to use very concentrated solutions since its IC50 against mammalian tumor cells is well below 1 microgram/mL.
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