Anguinomycin A CAS: 111278-01-4
MF: C31H44O6
MW: 512.7
An inhibitor of nuclear export of proteins.

Anguinomycin A (CAS 111278-01-4)

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Application: Anguinomycin A is an inhibitor of nuclear export of proteins
CAS Number: 111278-01-4
Purity: >95%
Molecular Weight: 512.7
Molecular Formula: C31H44O6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumor activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins.


References

1. Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. Hayakawa Y. et al. J. Antibiot. 1995, 48, 954. 2. New antitumor antibiotics, anguinomycins A and B. Hayakawa Y. et al. J. Antibiot. 1987, 40, 1349

Appearance :
Film
Physical State :
Solid
Derived From :
Streptomyces sp.
Solubility :
Soluble in methanol, and ethanol. Insoluble in DMSO.
Storage :
Store at -20° C
Boiling Point :
714.94° C at 760 mmHg (Predicted)
Density :
1.10 g/cm3 (Predicted)
Refractive Index :
n20D 1.55 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6444136
SMILES :
CC(CC=CC(=CC(C)C(=O)C(C)C(C(C)CC(=CC(=O)O)C)O)C)C=C(C)C=CC1CC=CC(=O)O1

Download SDS (MSDS)

Certificate of Analysis

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What is the solubility limit in EtOH?

Asked by: toczy
Thank you for your question. Anguinomycin A is an oil rather than a solid and readily dissolves in most common solvents except water. We could not find any detailed solubility study. It should not be necessary to use very concentrated solutions since its IC50 against mammalian tumor cells is well below 1 microgram/mL.
Answered by: Technical Support
Date published: 2019-01-26
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