Molecular structure of Angiotensin II, Human, CAS Number: 4474-91-3
Angiotensin II, Human (CAS 4474-91-3)
See product citations (3)
Alternate Names:
Ang II
Application:
Angiotensin II, Human is a peptide involved in the regulation of blood pressure
CAS Number:
4474-91-3
Purity:
≥93%
Molecular Weight:
1046.18
Molecular Formula:
C50H71N13O12
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Angiotensin II, Human plays an important role in the regulation of blood pressure and has strong vasoconstrictive effects. It also stimulates the release of aldosterone from the adrenal gland and inhibits adenylate cyclase activity in spontaneously hypertensive rats. Angiotensin II, Human increases the entry of Ca2+ in heart muscle via voltage-sensitive channels and activates myosin light chain kinase (MYLK). It also elicits an increase in voltage-dependent delayed rectifier K+ current in neurons and activates JAK2 in smooth muscle cells. Furthermore, Angiotensin II, Human activates FAK (p125FAK) and a cytosolic 115-120 kDa calcium-dependent tyrosine kinase in rat epithelial cells. It also activates c-Src (p60c-src), ERK1/2, JNK, and p38alpha (p38 MAP Kinase) in vascular smooth muscle cells.
Angiotensin II, Human (CAS 4474-91-3) References
- Decreased binding sites of angiotensin II in rat LY-80 and AH109A tumour and human gastric cancer using quantitative in vitro autoradiography. | Kohzuki, M., et al. 2000. Int Angiol. 19: 52-8. PMID: 10853686
- [Preoperative role of angiotensin II induced hypertension chemotherapy (IHC) in advanced gastric carcinoma]. | Sugiyama, K., et al. 1992. Gan To Kagaku Ryoho. 19: 203-9. PMID: 1736832
- Fluctuations in tumor blood flow under normotension and the effect of angiotensin II-induced hypertension. | Hori, K., et al. 1991. Jpn J Cancer Res. 82: 1309-16. PMID: 1752787
- Effect of angiotensin II on primary cardiac fibroblast matrix metalloproteinase activities. | Stacy, LB., et al. 2007. Perfusion. 22: 51-5. PMID: 17633135
- [Randomized controlled trial of induced hypertension chemotherapy (IHC) using angiotensin II human (TY-10721) in advanced gastric carcinoma (TY-10721 IHC Study Group Report)]. | Sato, H., et al. 1991. Gan To Kagaku Ryoho. 18: 451-60. PMID: 1900686
- Comparison of the effects of intravenously bolus-administered endothelin-1 and infused angiotensin II on the subcutaneous tumor blood flow in anesthetized rats. | Tanda, S., et al. 1991. Jpn J Cancer Res. 82: 958-63. PMID: 1910032
- [The effect of induced hypertension chemotherapy using angiotensin II human in patients with advanced gastric carcinoma--a histopathological evaluation on the excised stomachs]. | Nakamura, M., et al. 1991. Gan To Kagaku Ryoho. 18: 563-9. PMID: 2012398
- Effect of Tulbaghia violacea on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. | Raji, IA., et al. 2012. J Ethnopharmacol. 140: 98-106. PMID: 22222281
- Effects of aqueous leaf extract of Asystasia gangetica on the blood pressure and heart rate in male spontaneously hypertensive Wistar rats. | Mugabo, P. and Raji, IA. 2013. BMC Complement Altern Med. 13: 283. PMID: 24160568
- Association of the Serum Angiotensin II Level with Disease Severity in Severe Fever with Thrombocytopenia Syndrome Patients. | Cheng, J., et al. 2016. Intern Med. 55: 895-900. PMID: 27086801
- [A case of intrahepatic infusion chemotherapy with angiotensin II human for liver metastasis from early gastric cancer]. | Iwasaki, Y., et al. 1995. Gan To Kagaku Ryoho. 22: 1674-8. PMID: 7574790
- Effects of vaginal delivery and caesarian section on plasma renin activity and angiotensin II levels in human umbilical cord blood. | Lumbers, ER. and Reid, GC. 1977. Biol Neonate. 31: 127-33. PMID: 843548
- Angiotensin II (AII) induced hypertension chemotherapy (IHC) for unresectable gastric cancer: with reference to resection after down staging. | Sato, H., et al. 1995. World J Surg. 19: 836-42. PMID: 8553675
- Atypical angiotensin II receptors coupled to phosphoinositide turnover/calcium signalling in catfish hepatocytes. | Olivares-Reyes, JA., et al. 1997. Biochim Biophys Acta. 1357: 201-8. PMID: 9223623
Inhibitor of:
collectrin, NHE-5, NHE-7, and SPATA5L1.Activator of:
α-actinin-1, α-actinin-2, α-Syntrophin, β-Arrestin-2, 9030418K01Rik, A-Raf, A530099J19Rik, ACE, Ace3, ACTC1, ACY1L2, Adducin γ, ADX, AGTRAP, AIP1, AKD1, Aldosterone, Ang-2, Angiotensinase C, ANP, APLNR, AQP2, AQP4, ARG-Vasopressin, ARHGEF5_Arhgef5, AT1, AT2, ATP1AL1, ATP6AP1, AVP, Biglycan, BNP, BSPII, c-Fms/CSF-1R, c-Src, C130060K24Rik, CaMK1γ, Cardiotrophin-1, CAT-1, CD88, CDCP1, CGRP2, ChoK, CKR-8, CLIM-2, CRF21, cubilin, CYP11B, CYP11B1, Cyp21a1, Cyr61, D830046C22Rik, Dab1, DDAH II, Dear, desmoglein 3, DOCK 10, DOCK 5, E-Selectin, ECE-1, ECEL1, EG384813, Elk-1, EMMPRIN, ERK 1, ERK 2, ERK 4, ESAM, ET, ET-1, ETBR, FAK, FAPα, FRS2, FXYD2, FXYD4, Gα 11, Gα 14, Gα 15, Gγ 11, Gγ 13, Gγ 9, GAIP, GASP-1, GIT1, Gm14496, GNGT2, GPR112, GPR14, GPR141, GPR155, GPR32, GREB1L, GRK 2, GRK 4, HB-EGF, hCG_1651160, IRAP, ISLR2, JAB1, JAK2, JNK, karyopherin α2, KCTD18, KIR3.2, KLHL3, KRIT1, L-type Ca++ CP β1, MAFbx, MAS1L, megsin, MEK-1, MEK-5, MEK2, MEK3, MMP-3, MMP-9, MRAP2, MuRF1, MYH11, MYL4, MYL7, MYL9, MYLK, Myotrophin, Na+ CP type IIβ, NCC, NCCT, Net, Neurophysin I, NFATc2, NFATc4, NgBR, NHE-1, NHE-11, NHE-2, NHE-3, NHEDC2, NKCC1, NKCC2, NOR-1, Nox3, NOXA1, NuMA, Olfr393, OR4C46, OR5AN1, OTTMUSG00000016321, OTTMUSG00000016453, p38 α, p47-phox, PAI-1, PC-PLD2, PDGF-A, PDGF-B, PECAM-1, PI 3-kinase p85α, PLC β2, PLC 2, Pneumadin, Prokineticin-2, PYK2, Ras-GRF1, Reg Iα, Relaxin Receptor 4, Renin Receptor, RFPL1, RGP1, RGS16, RGS17, RGS8, Rho A, Rho T1, RNF148, RNF220, Rock-2, ROM-K, SLC6A19, smoothelin, SSTR3, TAB1, Tenomodulin, TGFβ3, Thrombospondin 1, TIMP-1, Tor1, Trav12n-1, Troponin I-SS, TRPC1, TRPC4, TRPC6, V-ATPase E, V1RA1, V1RA6, V1RA8, V1RD15, V1RD17, V1RD19, V1RD20, V1RD22, V1RD4, VAP-1, Vasculin, Vasorin, VCAM-1, VEGF, Visual Arrestin, Vmn1r121, Vmn1r224, Vmn2r17, Vmn2r7, Vmn2r71, Vmn2r73, Vmn2r75, Vmn2r77, Vmn2r79, Vmn2r85, Vmn2r86, Vmn2r87, WNK1, WNK2, WNK3, Xin, and ZF5128.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Angiotensin II, Human, 1 mg | sc-363643 | 1 mg | $51.00 | |||
Angiotensin II, Human, 5 mg | sc-363643A | 5 mg | $100.00 | |||
Angiotensin II, Human, 25 mg | sc-363643B | 25 mg | $310.00 | |||
Angiotensin II, Human, 100 mg | sc-363643C | 100 mg | $690.00 |