Molecular structure of Angeli′s salt, CAS Number: 13826-64-7
Angeli′s salt (CAS 13826-64-7)
See product citations (5)
Alternate Names:
Sodium α-oxyhyponitrite
Application:
Angeli′s salt is a NO donor salt with demonstrated cytotoxicity
CAS Number:
13826-64-7
Molecular Weight:
121.99
Molecular Formula:
N2O3•2Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Angeli′s salt is a nitroxyl anion (NO-) donor with cytotoxic effects. It spontaneously dissociates to release nitric oxide (NO) in a pH-dependent, first-order reaction, however, it has been found to instantaneously decompose at pH = 5. It is used to prepare nitroaromatics, nitroalkenes, and nitroalkanes.
Angeli′s salt (CAS 13826-64-7) References
- Opposite effects of nitric oxide and nitroxyl on postischemic myocardial injury. | Ma, XL., et al. 1999. Proc Natl Acad Sci U S A. 96: 14617-22. PMID: 10588754
- Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport. | Hrinczenko, BW., et al. 2000. Br J Haematol. 110: 412-9. PMID: 10971400
- Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion. | Miranda, KM., et al. 2001. J Biol Chem. 276: 1720-7. PMID: 11042174
- The potential of Angeli's salt to decrease nitric oxide scavenging by plasma hemoglobin. | He, X., et al. 2008. Free Radic Biol Med. 44: 1420-32. PMID: 18243145
- Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. | Maragos, CM., et al. 1991. J Med Chem. 34: 3242-7. PMID: 1956043
- The chemistry of nitroxyl-releasing compounds. | DuMond, JF. and King, SB. 2011. Antioxid Redox Signal. 14: 1637-48. PMID: 21235345
- Angeli's salt counteracts the vasoactive effects of elevated plasma hemoglobin. | Solomon, SB., et al. 2012. Free Radic Biol Med. 53: 2229-39. PMID: 23099417
- Reversible inactivation of dihydrolipoamide dehydrogenase by Angeli's salt. | Yan, LJ., et al. 2012. Sheng Wu Wu Li Hsueh Bao. 28: 341-350. PMID: 23139597
- Nitroglycerine and sodium trioxodinitrate: from the discovery to the preconditioning effect. | Pagliaro, P., et al. 2013. J Cardiovasc Med (Hagerstown). 14: 698-704. PMID: 23695182
- The nitroxyl donor Angeli's salt ameliorates Staphylococcus aureus-induced septic arthritis in mice. | Staurengo-Ferrari, L., et al. 2017. Free Radic Biol Med. 108: 487-499. PMID: 28419865
- Nitroxyl Delivered by Angeli's Salt Causes Short-Lasting Activation Followed by Long-Lasting Deactivation of Meningeal Afferents in Models of Headache Generation. | Stöckl, SK., et al. 2022. Int J Mol Sci. 23: PMID: 35216445
- Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance. | Velagic, A., et al. 2022. Br J Pharmacol. 179: 4117-4135. PMID: 35365882
- Antiglycation and Antioxidant Effect of Nitroxyl towards Hemoglobin. | Kosmachevskaya, OV., et al. 2022. Antioxidants (Basel). 11: PMID: 36290730
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Angeli′s salt, 10 mg | sc-202464 | 10 mg | $90.00 |