Ang-4 Antibody (A-6): sc-377497

Ang-4 Antibody (A-6) is a mouse monoclonal IgM antibody that detects Ang-4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Ang-4 antibody (A-6) is available as the non-conjugated form. Angiopoietin-4 (Ang-4) plays a crucial role in regulating angiogenesis and vascular permeability, making Ang-4 an important factor in various physiological and pathological processes, including inflammation and tumor progression. Ang-4 is primarily secreted by adipocytes and interacts with the Tie-2 receptor, similar to Ang-1 and Ang-2, but with distinct functional outcomes. While Ang-1 promotes blood vessel maturation, Ang-4 enhances endothelial cell survival and migration, contributing to new blood vessel formation. Unique expression patterns and functional roles of Ang-4 in different tissues underscore Ang-4′s significance in both normal physiology and disease states, particularly in cancer where angiogenesis drives tumor growth and metastasis. Anti-Ang-4 antibody (A-6) serves as an essential tool for researchers investigating angiogenesis mechanisms and the therapeutic potential of targeting angiopoietin pathways.

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Ang-4 Antibody (A-6) References:

1. Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3.  |  Kim, I., et al. 1999. FEBS Lett. 443: 353-6. PMID: 10025962
2. Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.  |  Valenzuela, DM., et al. 1999. Proc Natl Acad Sci U S A. 96: 1904-9. PMID: 10051567
3. Angiopoietins in angiogenesis and beyond.  |  Tsigkos, S., et al. 2003. Expert Opin Investig Drugs. 12: 933-41. PMID: 12783598
4. The temporal-spatial expression of VEGF, angiopoietins-1 and 2, and Tie-2 during tumor angiogenesis and their functional correlation with tumor neovascular architecture.  |  Tse, V., et al. 2003. Neurol Res. 25: 729-38. PMID: 14579791
5. tek, a novel tyrosine kinase gene located on mouse chromosome 4, is expressed in endothelial cells and their presumptive precursors.  |  Dumont, DJ., et al. 1992. Oncogene. 7: 1471-80. PMID: 1630810
6. Angiopoietin-4 promotes glioblastoma progression by enhancing tumor cell viability and angiogenesis.  |  Brunckhorst, MK., et al. 2010. Cancer Res. 70: 7283-93. PMID: 20823154
7. Angiopoietin-4 increases permeability of blood vessels and promotes lymphatic dilation.  |  Kesler, CT., et al. 2015. FASEB J. 29: 3668-77. PMID: 25977256
8. Therapeutic targeting of angiopoietins in tumor angiogenesis and cancer development.  |  Thapa, K., et al. 2023. Biochem Biophys Res Commun. 687: 149130. PMID: 37944468
9. The endothelial-specific receptor tyrosine kinase, tek, is a member of a new subfamily of receptors.  |  Dumont, DJ., et al. 1993. Oncogene. 8: 1293-301. PMID: 8386827
10. Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.  |  Sato, TN., et al. 1993. Proc Natl Acad Sci U S A. 90: 9355-8. PMID: 8415706
11. Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.  |  Davis, S., et al. 1996. Cell. 87: 1161-9. PMID: 8980223
12. Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.  |  Maisonpierre, PC., et al. 1997. Science. 277: 55-60. PMID: 9204896

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Ang-4 Antibody (A-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-Ang-4 Antibody (A-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Ang-4 Antibody (A-6) Specifications

Alternate Product Name: ANG4

Product Clone Name: A-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 5-41

Epitope Target: Ang-4

Epitope Species: mouse

Product Reactivity/Detection: Ang-4 (formerly designated Ang-3)

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Ang-4 Antibody (A-6): P: Blocking Peptide