Molecular structure of Amthamine dihydrobromide, CAS Number: 142457-00-9
Amthamine dihydrobromide (CAS 142457-00-9)
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Alternate Names:
2-Amino-5-(2-aminoethyl)-4-methylthiazole dihydrobromide
Application:
Amthamine dihydrobromide is an extremely selective H2 agonist
CAS Number:
142457-00-9
Molecular Weight:
319.06
Molecular Formula:
C6H11N3S•2HBr
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Amthamine dihydrobromide is an extremely selective Histamine H2 Receptor agonist. This compound has been shown to be slightly more potent than histamine itself.
Amthamine dihydrobromide (CAS 142457-00-9) References
- Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction. | Forward, NA., et al. 2009. J Immunol. 183: 3014-22. PMID: 19667094
- NAADP links histamine H1 receptors to secretion of von Willebrand factor in human endothelial cells. | Esposito, B., et al. 2011. Blood. 117: 4968-77. PMID: 21364192
- Histamine stimulates the proliferation of small and large cholangiocytes by activation of both IP3/Ca2+ and cAMP-dependent signaling mechanisms. | Francis, HL., et al. 2012. Lab Invest. 92: 282-94. PMID: 22064319
- Histamine H2 receptor activation exacerbates myocardial ischemia/reperfusion injury by disturbing mitochondrial and endothelial function. | Luo, T., et al. 2013. Basic Res Cardiol. 108: 342. PMID: 23467745
- The role of histamine in the regulation of the viability, proliferation and transforming growth factor β1 secretion of rat wound fibroblasts. | Wolak, M., et al. 2017. Pharmacol Rep. 69: 314-321. PMID: 28178593
- Histamine Regulates Molecular Clock Oscillations in Human Retinal Pigment Epithelial Cells via H1 Receptors. | Morioka, E., et al. 2018. Front Endocrinol (Lausanne). 9: 108. PMID: 29615980
- Histamine H4 receptor mediates chemotaxis of human lung mast cells. | Kay, LJ., et al. 2018. Eur J Pharmacol. 837: 38-44. PMID: 30148998
- Histamine Induces Microglia Activation and the Release of Proinflammatory Mediators in Rat Brain Via H1R or H4R. | Zhang, W., et al. 2020. J Neuroimmune Pharmacol. 15: 280-291. PMID: 31863333
- HYBID (alias KIAA1199/CEMIP) and hyaluronan synthase coordinately regulate hyaluronan metabolism in histamine-stimulated skin fibroblasts. | Yoshida, H., et al. 2020. J Biol Chem. 295: 2483-2494. PMID: 31949043
- Alterations in histamine responses between juvenile and adult urinary bladder urothelium, lamina propria and detrusor tissues. | Stromberga, Z., et al. 2020. Sci Rep. 10: 4116. PMID: 32139747
- Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats. | Chen, YN., et al. 2020. J Neuroinflammation. 17: 217. PMID: 32698899
- Histamine is involved in the regulation of collagen content in cultured heart myofibroblasts via H2, H3 and H4 histamine receptors. | Piera, L., et al. 2021. Biomed Rep. 15: 71. PMID: 34276989
- Ceefourin-1, a MRP4/ABCC4 inhibitor, induces apoptosis in AML cells enhanced by histamine. | Sahores, A., et al. 2023. Biochim Biophys Acta Gen Subj. 1867: 130322. PMID: 36773726
Inhibitor of:
Histamine H3 Receptor.Activator of:
Histamine H2 Receptor.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amthamine dihydrobromide, 10 mg | sc-361104 | 10 mg | $124.00 | |||
Amthamine dihydrobromide, 50 mg | sc-361104A | 50 mg | $490.00 |