AMTB hydrochloride (CAS 926023-82-7)
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Available in US only.
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AMTB hydrochloride is a chemical compound used in research focused on the study of ion channels, specifically the transient receptor potential melastatin 8 (TRPM8) channels. As an antagonist, AMTB hydrochloride is applied to investigate the role of TRPM8 channels in cellular signaling pathways that respond to cold temperatures and menthol. In neurobiology, it is used to elucidate the mechanisms underlying cold sensation and pain, providing insights into how TRPM8 channels contribute to these sensory processes. Additionally, researchers employ AMTB hydrochloride to probe the involvement of TRPM8 channels in various physiological responses, ranging from thermoregulation to nociception. The hydrochloride salt form of AMTB enhances its solubility in aqueous solutions, which is particularly useful in experimental assays that require precise dosing and consistent bioavailability.
AMTB hydrochloride (CAS 926023-82-7) References
- AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. | Lashinger, ES., et al. 2008. Am J Physiol Renal Physiol. 295: F803-10. PMID: 18562636
- Colon carcinogenesis is inhibited by the TRPM8 antagonist cannabigerol, a Cannabis-derived non-psychotropic cannabinoid. | Borrelli, F., et al. 2014. Carcinogenesis. 35: 2787-97. PMID: 25269802
- Differential Contribution of TRPA1, TRPV4 and TRPM8 to Colonic Nociception in Mice. | Mueller-Tribbensee, SM., et al. 2015. PLoS One. 10: e0128242. PMID: 26207981
- Inflammatory Effects of Menthol vs. Non-menthol Cigarette Smoke Extract on Human Lung Epithelial Cells: A Double-Hit on TRPM8 by Reactive Oxygen Species and Menthol. | Lin, AH., et al. 2017. Front Physiol. 8: 263. PMID: 28496415
- Involvement of TRPV3 and TRPM8 ion channel proteins in induction of mammalian cold-inducible proteins. | Fujita, T., et al. 2018. Biochem Biophys Res Commun. 495: 935-940. PMID: 29175331
- Role of TRP Channels in Dinoflagellate Mechanotransduction. | Lindström, JB., et al. 2017. Biol Bull. 233: 151-167. PMID: 29373067
- Menthol Cigarette Smoke Induces More Severe Lung Inflammation Than Non-menthol Cigarette Smoke Does in Mice With Subchronic Exposure - Role of TRPM8. | Lin, AH., et al. 2018. Front Physiol. 9: 1817. PMID: 30618827
- Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-κB signaling in the dorsal root ganglion of rats with neuropathic pain. | Cao, S., et al. 2019. J Pain Res. 12: 1287-1296. PMID: 31114308
- Regenerative Adaptation to Electrochemical Perturbation in Planaria: A Molecular Analysis of Physiological Plasticity. | Emmons-Bell, M., et al. 2019. iScience. 22: 147-165. PMID: 31765995
- Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain. | Rimola, V., et al. 2020. J Neurosci. 40: 9519-9532. PMID: 33158961
- Involvement of TRPM8 Channel in Radiation-Induced DNA Damage Repair Mechanism Contributing to Radioresistance of B16 Melanoma. | Nomura, D., et al. 2021. Biol Pharm Bull. 44: 642-652. PMID: 33658452
- Transient Receptor Potential Melastatin 8, a sensor of cold temperatures mediates expression of cyclin-dependent kinase inhibitor, p21/Cip1, a regulator of epidermal cell proliferation. | Fujino, T. 2022. J Toxicol Sci. 47: 117-123. PMID: 35236803
- Transient Receptor Potential Channels: Important Players in Ocular Pain and Dry Eye Disease. | Fakih, D., et al. 2022. Pharmaceutics. 14: PMID: 36145607
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMTB hydrochloride, 5 mg | sc-361103 | 5 mg | $141.00 | |||
| US: Only available in the US | ||||||
AMTB hydrochloride, 25 mg | sc-361103A | 25 mg | $473.00 | |||
| US: Only available in the US | ||||||