Amrinone CAS: 60719-84-8
MF: C10H9N3O
MW: 187.20
A selective cAMP phosphodiesterase inhibitor.

Amrinone (CAS 60719-84-8)

Amrinone | CAS 60719-84-8 is rated 5.0 out of 5 by 1.
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Application: A selective cAMP phosphodiesterase inhibitor
CAS Number: 60719-84-8
Purity: ≥98%
Molecular Weight: 187.20
Molecular Formula: C10H9N3O
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Amrinone is a selective cAMP PDE3A and PDE3B (phosphodiesterase) inhibitor with positive inotropic and vasodilatory activity. It is also cardiotonic.


References

Benotti, J.R., et al.: N. Engl. J. Med., 21, 1373 (1978), Ward, A., et al.: Drugs, 26, 468 (1983), Bottorff, M.B., et al.: Pharmacotherapy, 5, 227 (1985),

Physical State :
Solid
Solubility :
Soluble in methanol (sparingly), DMSO, hot acetic (slightly), DMF (slightly), and dilute inorganic acids. Insoluble in water, and chloroform.
Storage :
Store at 4° C
Melting Point :
294-297° C (dec.)
Boiling Point :
451.51° C at 760 mmHg (Predicted)
Density :
1.28 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Phosphodiesterase 4A: IC50 = 4.8 µM (human); Phosphodiesterase 3A: IC50 = 4.8 µM (human); Phosphodiesterase 3B: IC50 = 16 µM (human); Mannose-6-phosphate isomerase: IC50 = >50 µM (human); 1-acylglycerol-3-phosphate O-acyltransferase ABHD5: IC50 = 78816 nM (human); guinea pig: EC5050 = 7.4 µM
pK Values :
pKa: 12.05 (Predicted), pKb: 5.72 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DW2500000
PubChem CID :
3698
Merck Index :
14: 592
MDL Number :
MFCD00083228
EC Number :
262-390-0
SMILES :
C1=CN=CC=C1C2=CNC(=O)C(=C2)N

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Relevant assays for usage as analytical standards Relevant assays for usage as analytical standards.
Date published: 2015-06-08
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