Amprenavir CAS: 161814-49-9
MF: C25H35N3O6S
MW: 505.63
A selective HIV protease inhibitor.

Amprenavir (CAS 161814-49-9)

Amprenavir | CAS 161814-49-9 is rated 5.0 out of 5 by 1.
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Alternate Names: N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic Acid (3S)-Tetrahydro-3-furanyl Ester; 141W94; KVX-478; Agenerase; Prozei
Application: Amprenavir is a selective HIV protease inhibitor
CAS Number: 161814-49-9
Purity: ≥98%
Molecular Weight: 505.63
Molecular Formula: C25H35N3O6S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Amprenavir is a human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ± 12.5 ng/ml for wild-type HIV isolates. Like all HIV protease inhibitors, amprenavir interrupts the maturation phase of the HIV replicative cycle by forming an inhibitor-enzyme complex, which prevents HIV protease from binding with its normal substrates. This compound has an enzyme inhibition constant (Ki = 0.6 nM) that falls within the Ki range of the other protease inhibitors. Amprenavir is an inhibitor of HIV-1 Protease.


References

Adkins, J.C., et al.: Drugs, 55, 837 (1998)

Physical State :
Solid
Solubility :
Soluble in DMSO (16 mg/ml at 25° C), chloroform, dichloromethane, ethanol (101 mg/ml at 25° C), and water (partly).
Storage :
Store at -20° C
Melting Point :
72-74° C
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
HIV-1 Protease : IC50 = 1 nM (human); MT2: IC50 = 30 nM (human); MT4: IC50 = 100 nM (human)
Ki Data :
HIV-1 Protease : Ki= 0.04 nM (human)
pK Values :
pKa: 11.54 (Predicted), pKb: 1.76 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
65016
MDL Number :
MFCD00934214
Beilstein Registry :
10126027
SMILES :
CC(C)(C)N(C[[email protected]@H](O)[[email protected]](CC1=CC=CC=C1)NC(=O)O[[email protected]]1CCOC1)S(=O)(=O)C1=CC=C(N)C=C1

Download SDS (MSDS)

Certificate of Analysis

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What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Amprenavir (CAS 161814-49-9) has an appearance as a white solid.
Answered by: Technical Support
Date published: 2017-01-11
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Rated 5 out of 5 by from Dufek Dufek, MB. et al. (PubMed 23821186) reported that intestinal first-pass metabolism by cytochrome p450 and not p-glycoprotein is the major barrier to Amprenavir absorption. -SCBT Publication Review
Date published: 2015-06-03
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