AMPK alpha 1 Antibody (71.54): sc-130394
- AMPK alpha 1 Antibody (71.54) is a mouse monoclonal IgG2a κ, cited in 6 publications, provided at 100 µg/ml
- raised against recombinant AMPKα1 of human origin
- recommended for detection of AMPKα1 of human origin by WB, IP and ELISA
- See AMPK alpha 1/2 (D-6): sc-74461 for AMPK alpha 1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for AMPK alpha 1 Antibody (71.54). This work is in progress.
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AMPKα1 Antibody (71.54) is a mouse monoclonal IgG2a antibody that detects AMPKα1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). AMPKα1 is a crucial component of the AMP-activated protein kinase complex, which plays a vital role in cellular energy homeostasis by regulating metabolic pathways in response to energy stress. AMPKα1 is primarily located in the cytoplasm and can translocate to the nucleus under certain conditions, highlighting AMPKα1′s importance in cellular signaling and metabolic regulation. AMPKα1′s ability to sense and respond to changes in cellular energy levels is essential for maintaining ATP balance, particularly during periods of nutrient deprivation or increased energy demand. Additionally, AMPKα1 interacts with various proteins, including the upstream kinase LKB1, which is critical for activation, and downstream targets such as acetyl-CoA carboxylase and hydroxy-methylglutaryl-CoA reductase, which are key regulators of lipid and cholesterol metabolism. AMPKα1′s intricate regulation and interaction with these proteins underscore AMPKα1′s significance in metabolic diseases and potential therapeutic targets for conditions such as obesity and type 2 diabetes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMPK alpha 1 Antibody (71.54) | sc-130394 | 100 µg/ml | $333.00 |