Molecular structure of AMPK Activator, CAS Number: 849727-81-7
AMPK Activator (CAS 849727-81-7)
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Alternate Names:
5-(3-(4-(2-(4-Fluorophenyl)ethoxy)phenyl)propyl)furan-2-carboxylic acid, D942
Application:
AMPK Activator is a cell-permeable AMP-activated protein kinase (AMPK) activator and survivin inhibitor
CAS Number:
849727-81-7
Purity:
>95%
Molecular Weight:
368.40
Molecular Formula:
C22H21FO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AMPK Activator is a furancarboxylic acid derivative that can permeate the cell and partially inhibit the mitochondrial complex I. Research shows that AMPK Activator increases glucose uptake in L6 myocytes, and inhibits CCL2-induced mTORC1 activity and survivin expression in human prostate cancer PC-3 cells (sc-2220). In multiple myeloma cells, AMPK Activator inhibits cell growth.
AMPK Activator (CAS 849727-81-7) References
- Health status of illiterate adults: relation between literacy and health status among persons with low literacy skills. | Weiss, BD., et al. 1992. J Am Board Fam Pract. 5: 257-64. PMID: 1580173
- Identification of molecular target of AMP-activated protein kinase activator by affinity purification and mass spectrometry. | Kosaka, T., et al. 2005. Anal Chem. 77: 2050-5. PMID: 15801737
- Activation of adenosine monophosphate activated protein kinase inhibits growth of multiple myeloma cells. | Baumann, P., et al. 2007. Exp Cell Res. 313: 3592-603. PMID: 17669398
- Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2. | Kim, SJ., et al. 2008. Mol Cell Biol. 28: 1644-56. PMID: 18086876
- CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. | Roca, H., et al. 2009. Neoplasia. 11: 1309-17. PMID: 20019839
- GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene. | Kim, SJ., et al. 2010. J Lipid Res. 51: 3145-57. PMID: 20693566
- Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice. | Maida, A., et al. 2011. Diabetologia. 54: 339-49. PMID: 20972533
- Combination of D942 with curcumin protects cardiomyocytes from ischemic damage through promoting autophagy. | Yang, K., et al. 2013. J Cardiovasc Pharmacol Ther. 18: 570-81. PMID: 24057865
- The role of the autophagy in myocardial ischemia/reperfusion injury. | Ma, S., et al. 2015. Biochim Biophys Acta. 1852: 271-6. PMID: 24859226
- The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. | Ghosh, S., et al. 2015. Food Chem Toxicol. 83: 111-24. PMID: 26066364
- NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7. | Banskota, S., et al. 2015. Mol Cancer. 14: 123. PMID: 26116564
- Resveratrol Inhibits Porcine Intestinal Glucose and Alanine Transport: Potential Roles of Na⁺/K⁺-ATPase Activity, Protein Kinase A, AMP-Activated Protein Kinase and the Association of Selected Nutrient Transport Proteins with Detergent Resistant Membranes. | Klinger, S. and Breves, G. 2018. Nutrients. 10: PMID: 29510506
- Target deconvolution from phenotype-based drug discovery by using chemical proteomics approaches. | Kubota, K., et al. 2019. Biochim Biophys Acta Proteins Proteom. 1867: 22-27. PMID: 30392561
- Structure and Physiological Regulation of AMPK. | Yan, Y., et al. 2018. Int J Mol Sci. 19: PMID: 30423971
- Pre-treatment with D942, a furancarboxylic acid derivative, increases desiccation tolerance in an anhydrobiotic tardigrade Hypsibius exemplaris. | Kondo, K., et al. 2020. FEBS Open Bio. 10: 1774-1781. PMID: 32623826
Activator of:
AMPK.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMPK Activator, 1 mg | sc-203819A | 1 mg | $130.00 | |||
AMPK Activator, 5 mg | sc-203819 | 5 mg | $225.00 | |||
AMPK Activator, 10 mg | sc-203819B | 10 mg | $300.00 | |||
AMPK Activator, 50 mg | sc-203819C | 50 mg | $900.00 | |||
AMPK Activator, 100 mg | sc-203819D | 100 mg | $1700.00 |