Molecular structure of AMPA, CAS Number: 74341-63-2
AMPA (CAS 74341-63-2)
Alternate Names:
(R,S) AMPA
Application:
AMPA is the definitive agonist of the AMPA glutamatergic ionotropic receptor
CAS Number:
74341-63-2
Purity:
>97%
Molecular Weight:
186.17
Molecular Formula:
C7H10N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AMPA is a specific agonist of the GluR (AMPA receptor), an ionotropic receptor that recognizes glutamate as its natural substrate. The AMPA receptor is described to mediate a large amount of excitatory neurotransmission processes, and agonism at the AMPA receptor produces neuronal excitation and current induction. AMPA is employed as a tool to identify participation of the AMPA receptor in a neuronal response and to distinguish between activity at the AMPA receptor and at the glutamate-recognizing NMDA (sc-200458) and Kainic acid (sc-200454) receptors.
AMPA (CAS 74341-63-2) References
- Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. | Wang, LY., et al. 1991. Science. 253: 1132-5. PMID: 1653455
- Saffron extract and trans-crocetin inhibit glutamatergic synaptic transmission in rat cortical brain slices. | Berger, F., et al. 2011. Neuroscience. 180: 238-47. PMID: 21352900
- Periadolescent changes of D(2) -AMPA interactions in the rat nucleus accumbens. | Huppe-Gourgues, F. and O'Donnell, P. 2012. Synapse. 66: 1-8. PMID: 21842494
- Clozapine, but not haloperidol, enhances glial D-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes. | Tanahashi, S., et al. 2012. Br J Pharmacol. 165: 1543-55. PMID: 21880034
- TPM3 and TPM4 gene products segregate to the postsynaptic region of central nervous system synapses. | Guven, K., et al. 2011. Bioarchitecture. 1: 284-289. PMID: 22545181
- Activation of 5-HT7 serotonin receptors reverses metabotropic glutamate receptor-mediated synaptic plasticity in wild-type and Fmr1 knockout mice, a model of Fragile X syndrome. | Costa, L., et al. 2012. Biol Psychiatry. 72: 924-33. PMID: 22817866
- On the ligand binding profile and desensitization of plant ionotropic glutamate receptor (iGluR)-like channels functioning in MAMP-triggered Ca²⁺ influx. | Kwaaitaal, M., et al. 2012. Plant Signal Behav. 7: 1373-7. PMID: 22918498
- Leptin prevents hippocampal synaptic disruption and neuronal cell death induced by amyloid β. | Doherty, GH., et al. 2013. Neurobiol Aging. 34: 226-37. PMID: 22921154
- Molecular mechanisms of environmental organotin toxicity in mammals. | Kotake, Y. 2012. Biol Pharm Bull. 35: 1876-80. PMID: 23123459
- A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. | Farrell, MS., et al. 2013. Neuropsychopharmacology. 38: 854-62. PMID: 23303063
- Microtransplantation of cellular membranes from squid stellate ganglion reveals ionotropic GABA receptors. | Conti, L., et al. 2013. Biol Bull. 224: 47-52. PMID: 23493508
- Dual control of the vestibulosympathetic reflex following hypotension in rats. | Park, SE., et al. 2017. Korean J Physiol Pharmacol. 21: 675-686. PMID: 29200911
- The binding of [3H]AMPA, a structural analogue of glutamic acid, to rat brain membranes. | Honoré, T., et al. 1982. J Neurochem. 38: 173-8. PMID: 6125564
- Modulation of AMPA receptor unitary conductance by synaptic activity. | Benke, TA., et al. 1998. Nature. 393: 793-7. PMID: 9655394
Activator of:
GluR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMPA, 5 mg | sc-200437 | 5 mg | $153.00 | |||
AMPA, 50 mg | sc-200437A | 50 mg | $796.00 |