amorolfine (CAS 78613-35-1)

Amorolfine, a synthetic antifungal agent, has garnered significant attention in scientific research due to its broad-spectrum activity against various fungal pathogens. It functions by inhibiting the biosynthesis of ergosterol, an essential component of fungal cell membranes, through interference with the enzyme squalene epoxidase. This mechanism disrupts membrane integrity, leading to altered permeability and ultimately fungal cell death. Research on amorolfine has explored its efficacy against a wide range of fungal infections, including dermatophytes, yeasts, and molds. Studies have investigated its activity against common pathogens such as Candida species and dermatophyte fungi responsible for superficial infections like onychomycosis and tinea pedis. Additionally, research has delved into the antifungal resistance mechanisms and cross-resistance patterns associated with amorolfine, aiming to understand its potential limitations and identify strategies to overcome resistance. Furthermore, ongoing research efforts focus on optimizing formulations and delivery systems to enhance amorolfine′s bioavailability and tissue penetration, thus improving its efficacy. Amorolfine′s potent antifungal activity and unique mechanism of action make it a valuable tool in research aimed at combating fungal infections and understanding the underlying mechanisms of antifungal resistance, paving the way for the development of novel strategies in the field of mycology.