Amodiaquine Antibody (6D10): sc-80638

Amodiaquine Antibody (6D10) is a mouse monoclonal IgG2a antibody that detects Amodiaquine protein of non-species reactive by enzyme-linked immunosorbent assay (ELISA). Anti-Amodiaquine antibody (6D10) is available as a non-conjugated format. Amodiaquine, a 4-aminoquinoline compound, shares structural and functional similarities with chloroquine, and plays a crucial role in malaria treatment due to schizonticidal activity. Amodiaquine accumulates in malaria parasite lysosomes, leading to a loss of function detrimental to survival. The mechanism involves inhibiting heme polymerase activity, resulting in free heme accumulation, which is toxic to parasites. Amodiaquine has been used for over 40 years as both an antimalarial agent and for anti-inflammatory properties. Caution is warranted, as overdose can lead to severe side effects, including headache, drowsiness, visual disturbances, and potentially life-threatening conditions such as cardiovascular collapse and respiratory arrest.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Amodiaquine Antibody (6D10) References:

1. Amodiaquine during pregnancy.  |  Bhattarai, A., et al. 2004. Lancet Infect Dis. 4: 721-2; discussion 722. PMID: 15567117
2. Amodiaquine polymeric membrane electrode.  |  Malongo, TK., et al. 2006. J Pharm Biomed Anal. 41: 70-6. PMID: 16303276
3. A new approach to evaluate stability of amodiaquine and its metabolite in blood and plasma.  |  Blessborn, D., et al. 2006. J Pharm Biomed Anal. 41: 207-12. PMID: 16307860
4. Therapeutic efficacy of chloroquine or amodiaquine in combination with sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Papua New Guinea.  |  Jayatilaka, KD., et al. 2003. P N G Med J. 46: 125-34. PMID: 16454394
5. Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review.  |  Hwang, J., et al. 2006. Trop Med Int Health. 11: 789-99. PMID: 16771999
6. Amodiaquine, its desethylated metabolite, or both, inhibit the metabolism of debrisoquine (CYP2D6) and losartan (CYP2C9) in vivo.  |  Wennerholm, A., et al. 2006. Eur J Clin Pharmacol. 62: 539-46. PMID: 16783563
7. Efficacy, safety, and tolerability of amodiaquine plus sulphadoxine-pyrimethamine used alone or in combination for malaria treatment in pregnancy: a randomised trial.  |  Tagbor, H., et al. 2006. Lancet. 368: 1349-56. PMID: 17046467
8. Immunogenicity of amodiaquine in the rat.  |  Clarke, JB., et al. 1990. Int Arch Allergy Appl Immunol. 91: 335-42. PMID: 2210868
9. Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.  |  Krishna, S. and White, NJ. 1996. Clin Pharmacokinet. 30: 263-99. PMID: 8983859

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Amodiaquine Antibody (6D10) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Amodiaquine Antibody (6D10) Specifications

Alternate Product Name: Amodiaquine

Product Clone Name: 6D10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Amodiaquine

Epitope Species:

Product Reactivity/Detection: Amodiaquine

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Amodiaquine Antibody (6D10): N/A