Date published: 2026-5-18

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AMO 1618

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Application:
AMO 1618 is an anticholesterolemic agent
Molecular Weight:
446.36
Molecular Formula:
C19H31IN2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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AMO 1618 is a notable chemical inhibitor primarily utilized in plant biology research, where it plays a critical role in studying the biosynthesis and function of gibberellins, a class of plant hormones essential for growth regulation. This inhibitor operates by targeting and suppressing the activity of ent-kaurene oxidase, a pivotal enzyme in the gibberellin biosynthetic pathway. Through its mechanism of action, AMO 1618 allows researchers to explore the complex hormonal regulations that govern plant development, including stem elongation, germination, and flowering processes. By artificially manipulating gibberellin levels within plants, it serves as useful in elucidating the intricate hormonal interactions and genetic controls underlying plant physiology and morphology. This has profound implications for agricultural research, enabling the development of strategies to improve crop yield, stress resilience, and developmental efficiency.


AMO 1618 References

  1. Chemical alteration of carotene biosynthesis in Phycomyces blakesleeanus and mutants.  |  Lee, TC., et al. 1975. Appl Microbiol. 30: 988-93. PMID: 1211939
  2. Inverse effect of gibberellin and Amo-1618 on growth, catalase and peroxidase activity in cucumber seedlings.  |  HALEVY, AH. 1962. Experientia. 18: 74-6. PMID: 13903814
  3. GIBBERELLIN PRODUCTION IN PEA SEEDS DEVELOPING IN EXCISED PODS: EFFECT OF GROWTH RETARDANT AMO-1618.  |  BALDEV, B., et al. 1965. Science. 147: 155-7. PMID: 14220443
  4. GROWTH RETARDANTS: Effects on Gibberellin Biosynthesis and Other Metabolic Pathways.  |  Rademacher, W. 2000. Annu Rev Plant Physiol Plant Mol Biol. 51: 501-531. PMID: 15012200
  5. Evidence for a gibberellin biosynthetic origin of ceratopteris antheridiogen.  |  Warne, TR. and Hickok, LG. 1989. Plant Physiol. 89: 535-8. PMID: 16666578
  6. Phytochrome- and gibberellin-mediated regulation of abscisic acid metabolism during germination of photoblastic lettuce seeds.  |  Sawada, Y., et al. 2008. Plant Physiol. 146: 1386-96. PMID: 18184730
  7. Comparison of the enzymatic properties of ent-copalyl diphosphate synthases in the biosynthesis of phytoalexins and gibberellins in rice.  |  Hayashi, Y., et al. 2008. Biosci Biotechnol Biochem. 72: 523-30. PMID: 18256497
  8. Gibberellin precursor is involved in spore germination in the moss Physcomitrella patens.  |  Anterola, A., et al. 2009. Planta. 229: 1003-7. PMID: 19112579
  9. Opening of Iris flowers is regulated by endogenous auxins.  |  van Doorn, WG., et al. 2013. J Plant Physiol. 170: 161-4. PMID: 23218543
  10. Somatic embryogenesis in cell cultures of Glycine species.  |  Gamborg, OL., et al. 1983. Plant Cell Rep. 2: 209-12. PMID: 24258054
  11. The role of lipases in the germination of dormant apple embryos.  |  Smoleńska, G. and Lewak, S. 1974. Planta. 116: 361-70. PMID: 24458259
  12. Influence of minor plant constituents on porcine hepatic lipid metabolism. Impact on serum lipids.  |  Qureshi, AA., et al. 1987. Atherosclerosis. 64: 109-15. PMID: 3606707
  13. Effect of AMO 1618 on cholesterol and fatty acid metabolism in chickens and rats.  |  Qureshi, AA., et al. 1983. Atherosclerosis. 46: 203-16. PMID: 6838700
  14. Effect of sterol biosynthesis inhibitor, SSF-109, on cholesterol synthesis in isolated rat hepatocytes.  |  Seo, S., et al. 1993. Steroids. 58: 74-8. PMID: 8484187
  15. Subtractive hybridization between cDNAs from untreated and AMO-1618-treated cultures of Gibberella fujikuroi.  |  Jennings, JC., et al. 1996. Plant Cell Physiol. 37: 847-54. PMID: 8888622

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

AMO 1618, 250 mg

sc-221250
250 mg
$468.00