Molecular structure of AMN082 dihydrochloride, CAS Number: 83027-13-8
AMN082 dihydrochloride (CAS 83027-13-8)
Alternate Names:
N,N′-dibenzhydrylethane-1,2-diamine dihydrochloride; AMN082
Application:
AMN082 dihydrochloride is a selective agonist at mGluR-7
CAS Number:
83027-13-8
Molecular Weight:
465.46
Molecular Formula:
C28H28N2•2HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AMN082 Dihydrochloride is a potent and selective agonist at mGluR-7, acting at an allosteric site. mGluR-7 is a metabotropic glutamate receptor 7. AMN082 has been shown to promote the proliferation and differentiation of neural progenitor cells.
AMN082 dihydrochloride (CAS 83027-13-8) References
- A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. | Mitsukawa, K., et al. 2005. Proc Natl Acad Sci U S A. 102: 18712-7. PMID: 16339898
- The selective metabotropic glutamate receptor 7 allosteric agonist AMN082 inhibits inflammatory pain-induced and incision-induced hypersensitivity in rat. | Dolan, S., et al. 2009. Behav Pharmacol. 20: 596-604. PMID: 19667973
- Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice. | Hikichi, H., et al. 2010. Eur J Pharmacol. 639: 99-105. PMID: 20371235
- AMN082 promotes the proliferation and differentiation of neural progenitor cells with influence on phosphorylation of MAPK signaling pathways. | Tian, Y., et al. 2010. Neurochem Int. 57: 8-15. PMID: 20399820
- Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. | Li, X., et al. 2010. J Neurochem. 114: 1368-80. PMID: 20534005
- Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep. | Dolan, S., et al. 2011. Behav Pharmacol. 22: 582-8. PMID: 21597362
- The effects of metabotropic glutamate receptor 7 allosteric agonist N,N'-dibenzhydrylethane-1,2-diamine dihydrochloride on developmental sevoflurane neurotoxicity: role of extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase signaling pathway. | Wang, WY., et al. 2012. Neuroscience. 205: 167-77. PMID: 22244976
- A selective mGlu7 receptor antagonist MMPIP reversed antidepressant-like effects of AMN082 in rats. | Pałucha-Poniewiera, A. and Pilc, A. 2013. Behav Brain Res. 238: 109-12. PMID: 23085340
- Repeated administration of imipramine modifies GABAergic transmission in rat frontal cortex. | Wabno, J. and Hess, G. 2013. J Neural Transm (Vienna). 120: 711-9. PMID: 23180303
- Protective effect of FTY720 against sevoflurane-induced developmental neurotoxicity in rats. | Zhou, H., et al. 2013. Cell Biochem Biophys. 67: 591-8. PMID: 23471662
- JNK pathway may be involved in isoflurane-induced apoptosis in the hippocampi of neonatal rats. | Li, Y., et al. 2013. Neurosci Lett. 545: 17-22. PMID: 23603260
- Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082. | Konieczny, J. and Lenda, T. 2013. Pharmacol Rep. 65: 1194-203. PMID: 24399715
- Beta-arrestin1 and 2 differently modulate metabotropic glutamate receptor 7 signaling in rat developmental sevoflurane-induced neuronal apoptosis. | Wang, WY., et al. 2016. Neuroscience. 313: 199-212. PMID: 26621121
- Neuronal apoptosis may not contribute to the long-term cognitive dysfunction induced by a brief exposure to 2% sevoflurane in developing rats. | Lu, Y., et al. 2016. Biomed Pharmacother. 78: 322-328. PMID: 26898457
- Metabotropic Glutamate Receptor 7 (mGluR7) as a Target for Modulating Pain-evoked Activities of Neurons in the Hippocampal CA3 Region of Rats. | Wei, X., et al. 2017. CNS Neurol Disord Drug Targets. 16: 610-616. PMID: 27488423
Activator of:
mGluR-7.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AMN082 dihydrochloride, 10 mg | sc-200483 | 10 mg | $125.00 | |||
AMN082 dihydrochloride, 50 mg | sc-200483A | 50 mg | $510.00 |