Date published: 2025-12-19

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Ammonium Chloride (CAS 12125-02-9)

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CAS Number:
12125-02-9
Molecular Weight:
53.49
Molecular Formula:
NH4Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Ammonium chloride is a reagent used in a variety of industrial and research applications. Often used for the lysis of human red blood cells. Useful in protein isolation techniques. Also used in the study of basic calcium phosphate crystals in fibroblasts. Inhibits intracellular dissolution of basic calcium phosphate (BCP) crystals by alkalinizing phagolysosomes. Somewhat hygroscopic and strongly endothermic.


Ammonium Chloride (CAS 12125-02-9) References

  1. Ammonium chloride potentiation of streptozotocin-induced diabetes in juvenile pigs.  |  Korompai, FL., et al. 2000. Horm Metab Res. 32: 256-8. PMID: 10965929
  2. N-Chlorotaurine and ammonium chloride: an antiseptic preparation with strong bactericidal activity.  |  Gottardi, W., et al. 2007. Int J Pharm. 335: 32-40. PMID: 17196346
  3. AMMONIUM CHLORIDE DECALCIFICATION, AS MODIFIED BY CALCIUM INTAKE: THE RELATION BETWEEN GENERALIZED OSTEOPOROSIS AND OSTITIS FIBROSA.  |  Jaffe, HL., et al. 1932. J Exp Med. 56: 823-34. PMID: 19870105
  4. Injectable ammonium chloride used enterally for the treatment of persistent metabolic alkalosis in three pediatric patients.  |  Mathew, JT. and Bio, LL. 2012. J Pediatr Pharmacol Ther. 17: 98-103. PMID: 23118664
  5. Attenuation of murine coronavirus infection by ammonium chloride.  |  Mizzen, L., et al. 1985. Virology. 142: 378-88. PMID: 2997991
  6. A sustainable process for metal recycling from spent lithium-ion batteries using ammonium chloride.  |  Lv, W., et al. 2018. Waste Manag. 79: 545-553. PMID: 30343786
  7. Ammonium chloride-catalyzed green multicomponent synthesis of dihydropyrazine and tetrahydrodiazepine derivatives 'on water'.  |  Shaabani, A., et al. 2019. Mol Divers. 23: 585-592. PMID: 30465252
  8. Safety and efficacy of the feed additive consisting of ammonium chloride (Ammonium Chloride AF) for all ruminants, dogs and cats for the renewal of its authorisation (BASF SE).  |  , ., et al. 2022. EFSA J. 20: e07255. PMID: 35497378
  9. Ammonium chloride slows transport of the influenza virus hemagglutinin but does not cause mis-sorting in a polarized epithelial cell line.  |  Matlin, KS. 1986. J Biol Chem. 261: 15172-8. PMID: 3771570
  10. Effect of ammonium chloride on osmotic behavior of red cells in nonelectrolytes.  |  Sass, MD. 1979. Am J Physiol. 236: C238-43. PMID: 443365
  11. Ammonium chloride poisoning in chronic renal disease.  |  Levene, DL. and Knight, A. 1974. Can Med Assoc J. 111: 335 passim. PMID: 4850503
  12. Mode of inhibition of diphtheria toxin by ammonium chloride.  |  Kim, K. and Groman, NB. 1965. J Bacteriol. 90: 1557-62. PMID: 5854584
  13. The effect of ammonium chloride and glucagon on the metabolism of glutamine in isolated liver cells from starved rats.  |  Joseph, SK. and McGivan, JD. 1978. Biochim Biophys Acta. 543: 16-28. PMID: 708783
  14. Effects of ammonium chloride on urinary pH and cigarette smoking behavior.  |  Cherek, DR., et al. 1981. Clin Pharmacol Ther. 29: 762-70. PMID: 7226708

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Ammonium Chloride, 500 g

sc-506300
500 g
$20.00
US: (Out of Stock: Availability December 31, 2025)