Amlodipine besylate CAS: 111470-99-6
MF: C20H25ClN2O5 C6H6O3S
MW: 567.05
A calcium channel protein inhibitor.

Amlodipine besylate (CAS 111470-99-6)

Amlodipine besylate | CAS 111470-99-6 is rated 5.0 out of 5 by 1.
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Application: Amlodipine besylate is a calcium channel protein inhibitor
CAS Number: 111470-99-6
Purity: ≥98%
Molecular Weight: 567.05
Molecular Formula: C20H25ClN2O5 C6H6O3S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Amlodipine besylate is an L-type calcium channel protein inhibitor and blocker that contains antihypertensive properties. Amlodipine besylate also displays vasoprotective effects in cardiovascular disease and inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM). Amlodipine besylate has been shown to inhibit proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC50 = 25 μM).


References

1. Arrowsmith, J.E., et al. 1986. J. Med. Chem. 29: 1696-1702. PMID: 2943898
2. Burges, R.A., et al. 1987. J. Cardiovasc. Pharmacol. 9: 110-119. PMID: 2434785
3. Packer, M., et al. 1996. N. Engl. J. Med. 335: 1107-1114. PMID: 8813041
4. Yoshida, J., et al. 2003. Eur. J. Pharmacol. 472: 23-31. PMID: 12860469
5. Toba, H., et al. 2005 Hypertens. Res. 28: 689-700. PMID: 16392774

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in DMSO (≥20 mg/mL), water (10 mM), chloroform, ethanol (≥14 mg/mL), and methanol.
Storage :
Store at 4° C
Melting Point :
195-204° C
Boiling Point :
527.2° C at 760 mmHg (Predicted)
IC50 :
Ca2+-induced contractions : IC50 = 1.9 nM (depolarized rat aorta); proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells: IC50 = 25 µM; bTREK-1: IC50 = 0.43 µM; 35 mM KCl-induced contractions of pig coronary artery rings: IC50 = 22 nM; 35 mM KCl-induced contractions of human coronary artery rings: IC50 = 21 nM
pK Values :
pKa: 8.6
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
US7967700
PubChem CID :
60496
Merck Index :
14: 491
MDL Number :
MFCD00887594
SMILES :
CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O

Download SDS (MSDS)

Certificate of Analysis

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Amlodipine besylate (CAS 111470-99-6)  Product Citations

See how others have used Amlodipine besylate (CAS 111470-99-6). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 15983290  Whelton, PK. et al. 2005. Arch. Intern. Med. 165: 1401-1409.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Sathyanarayana Rao Sathyanarayana Rao, KN. et al. (PubMed 20593148) tested amlodipine besylate, a L-type calcium channel blocker well known for its anti-hypertensive properties, as a potential anti-convulsant. Found that amlodipine besylate reduced seizures in a concentration dependent manner in inbred albino mice. -SCBT Publication Review
Date published: 2015-02-10
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