Date published: 2025-12-11

1-800-457-3801

SCBT Portrait Logo
Seach Input

Amitriptyline N-Oxide (CAS 4317-14-0)

0.0(0)
Write a reviewAsk a question

Alternate Names:
3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine N-Oxide
CAS Number:
4317-14-0
Molecular Weight:
293.4
Molecular Formula:
C20H23NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Amitriptyline N-oxide is a metabolite of amitriptyline, formed through the biotransformation process in which an oxygen atom is added to the nitrogen atom in the amitriptyline molecule. This oxidation process is part of the metabolic pathway some substances undergo to become more water-soluble and easier to eliminate. Studying metabolites such as amitriptyline N-oxide is for understanding the complete kinetic profile of a molecule. It helps in identifying the pathways through which a molecule is metabolized and eventually excreted. Amitriptyline N-oxide serves as a case study in how specific functional groups contribute to the reactivity and interactions of organic compounds.


Amitriptyline N-Oxide (CAS 4317-14-0) References

  1. Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides.  |  Skálová, L., et al. 2000. Chem Biol Interact. 126: 185-200. PMID: 10862817
  2. Metabolic fate of FCE 22716, a new antihypertensive agent, and of its N-oxide (FCE 24220) in the rat.  |  Cocchiara, G., et al. 1992. Drug Metabol Drug Interact. 10: 185-97. PMID: 1424640
  3. High-performance liquid chromatographic determination of amitriptyline and its main metabolites using a silica column with reversed-phase eluent. Application in mice.  |  Coudore, F., et al. 1992. J Chromatogr. 584: 249-55. PMID: 1484109
  4. A rapid methodology for the characterization of dialkyl tertiary amine-N-oxide metabolites using structurally dependent dissociation pathways and reconstructed ion current chromatograms.  |  Holman, SW., et al. 2010. Anal Chem. 82: 2347-54. PMID: 20158225
  5. REM-suppressing effects of amitriptyline and amitriptyline-N-oxide after acute medication in healthy volunteers: results of two uncontrolled pilot trials.  |  Riemann, D., et al. 1990. Pharmacopsychiatry. 23: 253-8. PMID: 2284326
  6. Persistence of the tricyclic antidepressant drugs amitriptyline and nortriptyline in agriculture soils.  |  Li, H., et al. 2013. Environ Toxicol Chem. 32: 509-16. PMID: 23280809
  7. The stability of amitriptyline N-oxide and clozapine N-oxide on treated and untreated dry blood spot cards.  |  Temesi, D., et al. 2013. J Pharm Biomed Anal. 76: 164-8. PMID: 23333684
  8. The mitochondrial amidoxime reducing component (mARC): involvement in metabolic reduction of N-oxides, oximes and N-hydroxyamidinohydrazones.  |  Jakobs, HH., et al. 2014. ChemMedChem. 9: 2381-7. PMID: 25045021
  9. What is the contribution of human FMO3 in the N-oxygenation of selected therapeutic drugs and drugs of abuse?  |  Wagmann, L., et al. 2016. Toxicol Lett. 258: 55-70. PMID: 27320963
  10. Combination headache: practical experience with a combination of a beta-blocker and an antidepressive.  |  Pfaffenrath, V., et al. 1986. Cephalalgia. 6 Suppl 5: 25-32. PMID: 3802192
  11. Development of a rapid extraction and high-performance liquid chromatographic separation for amitriptyline and six biological metabolites.  |  Kiel, JS., et al. 1986. J Chromatogr. 383: 119-27. PMID: 3818830
  12. Pharmacokinetics of amitriptyline N-oxide in rats after single and prolonged oral administration.  |  Melzacka, M. and Danek, L. 1983. Pharmacopsychiatria. 16: 30-4. PMID: 6828552
  13. Biotransformation of amitriptyline in depressive patients: urinary excretion of seven metabolites.  |  Vandel, B., et al. 1982. Eur J Clin Pharmacol. 22: 239-45. PMID: 7106157
  14. Neuropharmacological properties of amitriptyline, nortriptyline and their metabolites.  |  Hyttel, J., et al. 1980. Acta Pharmacol Toxicol (Copenh). 47: 53-7. PMID: 7395525
  15. Determination of amitriptyline-N-oxide, amitriptyline and nortriptyline in serum and plasma by high-performance liquid chromatography.  |  Jensen, KM. 1980. J Chromatogr. 183: 321-9. PMID: 7419649

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Amitriptyline N-Oxide, 100 mg

sc-481008
100 mg
$380.00