Date published: 2026-1-9

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Amiprofos methyl (CAS 36001-88-4)

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Alternate Names:
N-[methoxy-(4-methyl-2-nitrophenoxy)phosphinothioyl]propan-2-amine
Application:
Amiprofos methyl is a herbicide
CAS Number:
36001-88-4
Purity:
≥98%
Molecular Weight:
304.30
Molecular Formula:
C11H17N2O4PS
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Amiprofos methyl, a mitotic inhibitor, plays a significant role in the study of cell division and cytoskeletal dynamics. Its mechanism of action involves the inhibition of microtubule polymerization, a critical process for mitotic spindle formation during cell division. By interfering with microtubule assembly, amiprofos methyl effectively halts the mitotic process, making it useful for researchers investigating the intricate events of mitosis and the regulation of the cell cycle. This inhibition provides insights into the cellular responses to disrupted mitosis, including the activation of mitotic checkpoints, apoptosis pathways, and the potential for cell cycle arrest. Additionally, its impact on microtubule dynamics offers a window into understanding the roles of microtubules in cellular processes beyond cell division, such as intracellular transport and cell morphology. Consequently, amiprofos methyl is utilized in various research applications to dissect the molecular underpinnings of cell division, explore the mechanisms governing cellular integrity, and unravel the complex interplay between microtubules and cell cycle progression.


Amiprofos methyl (CAS 36001-88-4) References

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  2. Competitive Inhibition of High-Affinity Oryzalin Binding to Plant Tubulin by the Phosphoric Amide Herbicide Amiprophos-Methyl.  |  Murthy, JV., et al. 1994. Plant Physiol. 105: 309-320. PMID: 12232204
  3. Chromosome doubling procedures of onion (Allium cepa L.) gynogenic embryos.  |  Jakse, M., et al. 2003. Plant Cell Rep. 21: 905-10. PMID: 12789509
  4. Transgenic rice containing human CYP2B6 detoxifies various classes of herbicides.  |  Hirose, S., et al. 2005. J Agric Food Chem. 53: 3461-7. PMID: 15853388
  5. Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants.  |  Kawahigashi, H., et al. 2005. Transgenic Res. 14: 907-17. PMID: 16315095
  6. The Shibata Shift and the Transformation of Etioplasts to Chloroplasts in Wheat with Clomazone (FMC 57020) and Amiprophos-Methyl (Tokunol M).  |  Artus, NN., et al. 1992. Plant Physiol. 98: 253-63. PMID: 16668622
  7. Inhibition of Plant Microtubule Polymerization in vitro by the Phosphoric Amide Herbicide Amiprophos-Methyl.  |  Morejohn, LC. and Fosket, DE. 1984. Science. 224: 874-6. PMID: 17743197
  8. Highly effective cell synchronization in plant roots by hydroxyurea and amiprophos-methyl or colchicine.  |  Pan, WH., et al. 1993. Genome. 36: 387-90. PMID: 18469996
  9. Synthesis and evaluation of phosphoramidate and phosphorothioamidate analogues of amiprophos methyl as potential antimalarial agents.  |  Mara, C., et al. 2011. Bioorg Med Chem Lett. 21: 6180-3. PMID: 21889338
  10. Efficient induction by amiprophos-methyl and flow-cytometric sorting of micronuclei in Nicotiana plumbaginifolia.  |  de Laat, AM., et al. 1987. Planta. 172: 473-8. PMID: 24226065
  11. Doubled haploid production from Spanish onion (Allium cepa L.) germplasm: embryogenesis induction, plant regeneration and chromosome doubling.  |  Fayos, O., et al. 2015. Front Plant Sci. 6: 384. PMID: 26074944
  12. Induction of adventitious shoots and tetraploids in Antirrhinum majus L. by treatment of antimitotic agents in vitro without plant growth regulators.  |  Hlaing, TS., et al. 2021. Plant Biotechnol (Tokyo). 38: 145-152. PMID: 34177334
  13. Selective inhibition of tubulin synthesis by amiprophos methyl during flagellar regeneration in Chlamydomonas reinhardi.  |  Collis, PS. and Weeks, DP. 1978. Science. 202: 440-2. PMID: 568309

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Amiprofos methyl, 1 g

sc-210800
1 g
$442.00

Amiprofos methyl, 5 g

sc-210800A
5 g
$818.00