Molecular structure of Amikacin (free base), CAS Number: 37517-28-5
Amikacin (free base) (CAS 37517-28-5)
See product citations (2)
Alternate Names:
N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A
Application:
Amikacin (free base) is an aminoglycoside antibiotic derived from kanamycin A
CAS Number:
37517-28-5
Molecular Weight:
585.60
Molecular Formula:
C22H43N5O13
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
Amikacin (free base) is an aminoglycoside antibiotic derived from kanamycin A. Effective against Gram-negative and Gram-positive bacteria. As a free base, amikacin is the non-protonated form of the drug, which is the active form that can penetrate bacterial cells and exert its antimicrobial effects. Amikacin (free base) works by inhibiting bacterial protein synthesis, thereby preventing the growth and proliferation of susceptible bacteria.
Amikacin (free base) (CAS 37517-28-5) References
- Once-a-day individualized amikacin dosing for suspected infection at birth based on population pharmacokinetic models. | Labaune, JM., et al. 2001. Biol Neonate. 80: 142-7. PMID: 11509814
- In vitro and in vivo evaluation of ferric-hyaluronate implants for delivery of amikacin sulfate to the tarsocrural joint of horses. | Cribb, NC., et al. 2009. Vet Surg. 38: 498-505. PMID: 19538672
- Optimization of freeze-drying condition of amikacin solid lipid nanoparticles using D-optimal experimental design. | Varshosaz, J., et al. 2012. Pharm Dev Technol. 17: 187-94. PMID: 21047276
- Pharmacokinetics of amikacin in plasma and selected body fluids of healthy horses after a single intravenous dose. | Pinto, N., et al. 2011. Equine Vet J. 43: 112-6. PMID: 21143642
- Effect of emptying the vasculature before performing regional limb perfusion with amikacin in horses. | Sole, A., et al. 2016. Equine Vet J. 48: 737-740. PMID: 26278891
- The amikacin research program: a stepwise approach to validate dosing regimens in neonates. | Smits, A., et al. 2017. Expert Opin Drug Metab Toxicol. 13: 157-166. PMID: 27623706
- Effects of tourniquet number and exsanguination on amikacin concentrations in the radiocarpal and distal interphalangeal joints after low volume intravenous regional limb perfusion in horses. | Schoonover, MJ., et al. 2017. Vet Surg. 46: 675-682. PMID: 28460426
- Evaluation of haemodialysis as a protective technique for preventing high daily dose amikacin nephrotoxicity: an experimental study in an ovine model. | Pouzot-Nevoret, C., et al. 2017. Int J Antimicrob Agents. 50: 148-154. PMID: 28689868
- Antibacterial activity of human simulated epithelial lining fluid concentrations of amikacin inhale alone and in combination with meropenem against Acinetobacter baumannii. | Ghazi, IM., et al. 2017. Infect Dis (Lond). 49: 831-839. PMID: 28758820
- Pharmacodynamics of inhaled amikacin (BAY 41-6551) studied in an in vitro pharmacokinetic model of infection. | Bowker, KE., et al. 2018. J Antimicrob Chemother. 73: 1305-1313. PMID: 29562340
- Dried plasma spots for therapeutic monitoring of amikacin: Validation of an UHPLC-MS/MS assay and pharmacokinetic application. | da Silva, ACC., et al. 2020. J Pharm Biomed Anal. 184: 113201. PMID: 32113122
- Breaking the barriers for the delivery of amikacin: Challenges, strategies, and opportunities. | Maxwell, A., et al. 2021. Life Sci. 284: 119883. PMID: 34390724
- Concentration of amikacin sulphate in synovial fluid when given in combination with dexamethasone phosphate in intravenous regional limb perfusion in standing horses. | Gustafsson, K., et al. 2022. J Vet Pharmacol Ther. 45: 409-414. PMID: 35307838
- Lipid-based slow-release formulation of amikacin sulfate reduces foreign body-associated infections in mice. | Roehrborn, AA., et al. 1995. Antimicrob Agents Chemother. 39: 1752-5. PMID: 7486914
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amikacin (free base), 1 g | sc-278692 | 1 g | $69.00 | |||
Amikacin (free base), 5 g | sc-278692A | 5 g | $165.00 |