Click on image or enlarge button to enlarge

Amidepsine A (CAS 169181-28-6)

5.0(1)

Write a review Ask a question

Application: An inhibitor of diacylglycerol acyltransferase

CAS Number: 169181-28-6

Purity: ≥95%

Molecular Weight: 567.54

Molecular Formula: C₂₉H₂₉NO₁₁

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

SDS & Certificate of Analysis

Amidepsine A is an inhibitor of DGAT (diacylglycerol acyltransferase). This shows inhibitory effect in rat liver microsomes (IC₅₀=10.2μM) and Raji cells (IC₅₀=15.5μM). It has excessive accumulation of triacetylglycerol produced by DGAT which may cause fatty liver, obesity, and hypertriglyceridemia, and may lead to atherosclerosis, diabetes and metabolic disorders.

References

H. Tomoda, et al.; J. Antibiot. 48, 937 (1995). H. Tomoda, et al.; J. Antibiot. 48, 942 (1995).

Appearance :

Powder

Physical State :

Solid

Derived From :

fungal strain FO-2942

Solubility :

Soluble in methanol, ethyl acetate, and benzene. Insoluble in water, and hexane.

Storage :

Store at -20° C

Boiling Point :

773.25° C at 760 mmHg (Predicted)

Density :

1.36 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.61 (Predicted)

IC50 :

LIver microsomes: IC₅₀ = 10.2 µM (rat); Raji cells: IC₅₀ = 15.5 µM

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

PubChem CID :

10099481

SMILES :

CC1=CC(=CC(=C1C(=O)NC(C)C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Rated 5 out of 5 by Anonymous from Good Good.

Date published: 2015-09-11

The email address or password you have entered is incorrect. Hide

* Required fields

Email*

Password*

Forgot your password?

SIGN IN WITH SOCIAL ACCOUNT

Please sign in using your account on one of the following social networks.

{* mergeAccounts {"custom": true} *}

{| rendered_current_photo |}

{| current_displayName |}
{| current_emailAddress |}

{| foundExistingAccountText |}.

{| moreInfoHoverText |}

{| moreInfoText |}

{| rendered_existing_provider_photo |}

{| existing_displayName |}
{| existing_provider_emailAddress |}

Created {| existing_createdDate |} at {| existing_siteName |}

Connect with your {| existing_siteName |} account?

{* backButton *}

{| connect_button |}

Don't have an account?

Email address already exists, please enter a new valid email address. Hide

* Required fields

PERSONAL INFORMATION

First Name*

Last Name*

LOGIN INFORMATION

Email*

Password*

Confirm Password*

Why create an account?

Creating an account with us makes your shopping experience much easier and faster. You can save favorites, save cart, check order status and speed through checkout with saved addresses, payment methods and more.

Already have an account?

Choose a Store

Choose a Language

Choose a Currency