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Amidepsine A is an inhibitor of DGAT (diacylglycerol acyltransferase). This shows inhibitory effect in rat liver microsomes (IC50=10.2μM) and Raji cells (IC50=15.5μM). It has excessive accumulation of triacetylglycerol produced by DGAT which may cause fatty liver, obesity, and hypertriglyceridemia, and may lead to atherosclerosis, diabetes and metabolic disorders.
H. Tomoda, et al.; J. Antibiot. 48, 937 (1995). H. Tomoda, et al.; J. Antibiot. 48, 942 (1995).
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