Amidepsine A CAS: 169181-28-6
MF: C29H29NO11
MW: 567.54
An inhibitor of diacylglycerol acyltransferase.
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Amidepsine A (CAS 169181-28-6)

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Application: Amidepsine A is an inhibitor of diacylglycerol acyltransferase
CAS Number: 169181-28-6
Purity: ≥95%
Molecular Weight: 567.54
Molecular Formula: C29H29NO11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

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Amidepsine A is an inhibitor of DGAT (diacylglycerol acyltransferase). This shows inhibitory effect in rat liver microsomes (IC50=10.2μM) and Raji cells (IC50=15.5μM). It has excessive accumulation of triacetylglycerol produced by DGAT which may cause fatty liver, obesity, and hypertriglyceridemia, and may lead to atherosclerosis, diabetes and metabolic disorders.


References

H. Tomoda, et al.; J. Antibiot. 48, 937 (1995). H. Tomoda, et al.; J. Antibiot. 48, 942 (1995).

Appearance :
Powder
Physical State :
Solid
Derived From :
fungal strain FO-2942
Solubility :
Soluble in methanol, ethyl acetate, and benzene. Insoluble in water, and hexane.
Storage :
Store at -20° C
Boiling Point :
773.25° C at 760 mmHg (Predicted)
Density :
1.36 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
LIver microsomes: IC50 = 10.2 µM (rat); Raji cells: IC50 = 15.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
10099481
SMILES :
CC1=CC(=CC(=C1C(=O)NC(C)C(=O)O)O)OC(=O)C2=C(C=C(C=C2C)OC(=O)C3=C(C=C(C=C3C)OC)OC)O

Download SDS (MSDS)

Certificate of Analysis

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Date published: 2015-09-11
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