Date published: 2025-11-4

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Amdinocillin (CAS 32887-01-7)

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Alternate Names:
Mecillinam
Application:
Amdinocillin is an antibacterial compound
CAS Number:
32887-01-7
Molecular Weight:
325.43
Molecular Formula:
C15H23N3O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Amdinocillin, recognized for its targeted antibacterial properties, plays a role in the realm of microbiological research, particularly against gram-negative bacteria. This compound operates through a distinctive mechanism of action, inhibiting the synthesis of bacterial cell walls, thereby leading to bacterial cell lysis and ultimately, eradication of the infection. Its effectiveness hinges on its ability to bind to penicillin-binding proteins (PBPs) located in the bacterial cell membrane, which are essential for the cross-linking process that gives the cell wall its strength and rigidity. By disrupting this critical process, amdinocillin renders the bacteria incapable of maintaining their structural integrity, leading to their demise.


Amdinocillin (CAS 32887-01-7) References

  1. Amdinocillin (Mecillinam) resistance mutations in clinical isolates and laboratory-selected mutants of Escherichia coli.  |  Thulin, E., et al. 2015. Antimicrob Agents Chemother. 59: 1718-27. PMID: 25583718
  2. Amdinocillin treatment of catheter-associated bacteriuria in rabbits.  |  Olson, ME., et al. 1989. J Infect Dis. 159: 1065-72. PMID: 2656876
  3. Protective effect of amdinocillin against emergence of resistance to ceftazidime in Enterobacter cloacae.  |  Yourassowsky, E., et al. 1988. Antimicrob Agents Chemother. 32: 1632-5. PMID: 3075433
  4. Results from a Prospective In Vitro Study on the Mecillinam (Amdinocillin) Susceptibility of Enterobacterales.  |  Fuchs, F. and Hamprecht, A. 2019. Antimicrob Agents Chemother. 63: PMID: 30917983
  5. Amdinocillin: a novel penicillin. Antibacterial activity, pharmacology and clinical use.  |  Neu, HC. 1985. Pharmacotherapy. 5: 1-10. PMID: 3885172
  6. Amdinocillin: use alone or in combination with cefoxitin or carbenicillin-ticarcillin.  |  Lawson, RD., et al. 1983. Am J Med. 75: 113-8. PMID: 6310998
  7. Efficacy, pharmacology, and safety of amdinocillin in treatment of neonates.  |  de Louvois, J. and Mulhall, A. 1983. Am J Med. 75: 119-24. PMID: 6310999
  8. Morphologic changes produced by amdinocillin alone and in combination with beta-lactam antibiotics: in vitro and in vivo.  |  Kramer, MJ., et al. 1983. Am J Med. 75: 30-41. PMID: 6311003
  9. Amdinocillin therapy of experimental animal infections.  |  Gordin, FM. and Sande, MA. 1983. Am J Med. 75: 48-53. PMID: 6311005
  10. Amdinocillin pharmacokinetics. Simultaneous administration with cephalothin and cerebrospinal fluid penetration.  |  Gambertoglio, JG., et al. 1983. Am J Med. 75: 54-9. PMID: 6311006
  11. Review of clinical experience with amdinocillin monotherapy and comparative studies.  |  Demos, CH. and Green, E. 1983. Am J Med. 75: 72-81. PMID: 6311009
  12. Combination amdinocillin and cefoxitin therapy of multiply-resistant Serratia marcescens urinary tract infections.  |  Ward, TT., et al. 1983. Am J Med. 75: 85-9. PMID: 6311011
  13. Penicillin-binding proteins and role of amdinocillin in causing bacterial cell death.  |  Neu, HC. 1983. Am J Med. 75: 9-20. PMID: 6311012

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Amdinocillin, 1 g

sc-207277
1 g
$126.00