AMBP Antibody (532): sc-81948

AMBP Antibody (532) is a mouse monoclonal IgG1 antibody that detects AMBP protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-AMBP antibody (532) is available as the non-conjugated format. The AMBP (α-1-Microglobulin/bikunin precursor) gene encodes a protein precursor that is cleaved to produce two distinct proteins: α-1-Microglobulin and Bikunin. The α-1-Microglobulin component, also known as protein HC, is a member of the lipocalin superfamily and is primarily secreted in plasma, urine, and cerebrospinal fluid. α-1-Microglobulin plays a crucial role in the body′s immune response, exhibiting immunosuppressive properties by modulating cytokine secretion and inhibiting antigen-induced lymphocyte proliferation, which is vital for maintaining immune homeostasis and preventing excessive inflammatory responses. Additionally, α-1-Microglobulin possesses reductase and dehydrogenase activities, contributing to the reduction of biological pro-oxidants, thereby protecting tissues from oxidative damage. Bikunin, also known as inter-α-trypsin inhibitor light chain, is a Kunitz-type protease inhibitor that is widely expressed and stored in the granules of human connective tissue mast cells. Bikunin plays a significant role in preventing autodigestion by exocrine enzymes and is implicated in the anti-inflammatory immune response, particularly in the context of renal diseases such as urolithiasis.

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AMBP Antibody (532) References:

1. Role of inter-alpha-inhibitor and its related proteins in experimentally induced calcium oxalate urolithiasis. Localization of proteins and expression of bikunin gene in the rat kidney.  |  Atmani, F., et al. 1999. Urol Res. 27: 63-7. PMID: 10092155
2. Immunohistochemical demonstration of inter-alpha-trypsin inhibitor light chain (bikunin) in human mast cells.  |  Ide, H., et al. 1999. Cell Tissue Res. 297: 149-54. PMID: 10398892
3. Inflammation-induced systemic proteolysis of inter-alpha-inhibitor in plasma from patients with sepsis.  |  Balduyck, M., et al. 2000. J Lab Clin Med. 135: 188-98. PMID: 10695665
4. Expression of inter-alpha-trypsin inhibitor light chain (bikunin) in human pancreas.  |  Itoh, H., et al. 1996. J Biochem. 120: 271-5. PMID: 8889810
5. Posttranslational modifications of human inter-alpha-inhibitor: identification of glycans and disulfide bridges in heavy chains 1 and 2.  |  Olsen, EH., et al. 1998. Biochemistry. 37: 408-16. PMID: 9425062
6. Inter-alpha-inhibitor in calcium stones.  |  Dawson, CJ., et al. 1998. Clin Sci (Lond). 95: 187-93. PMID: 9680501

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AMBP Antibody (532) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-AMBP Antibody (532) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AMBP Antibody (532) Specifications

Alternate Product Name: AMBP

Product Clone Name: 532

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 19-353

Epitope Target: AMBP

Epitope Species: human

Product Reactivity/Detection: AMBP

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for AMBP Antibody (532): N/A