Date published: 2025-10-11

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Amauromine (CAS 88360-87-6)

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Alternate Names:
Antibiotic FR 900220; WF 6237
Application:
Amauromine is a CB1 and Calcium Channel antagonist
CAS Number:
88360-87-6
Molecular Weight:
508.7
Molecular Formula:
C32H36N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Amauromine is a secondary metabolite produced by the soil bacterium Streptomyces sp.. It belongs to the quinone family of compounds, recognized for their redox properties, which are critical in various biochemical processes. Amauromine exhibits a unique ability to act as an electron shuttle, facilitating redox reactions in biological systems. This characteristic makes it a useful tool in the study of microbial electron transfer processes, particularly in the context of microbial fuel cells and bioremediation research. Amauromine′s electron shuttling capability enables researchers to explore the efficiency of electron transfer between microbial communities and electrodes or between different organisms in a mixed-culture environment. Additionally, amauromine has been utilized in studies focusing on the antimicrobial properties of quinones, where it aids in understanding the mechanisms through which these compounds exert inhibitory effects on bacterial growth, often by generating reactive oxygen species that damage cellular components. The chemical′s role in inducing oxidative stress is also explored in environmental science, particularly in the detoxification of pollutants. This compound provides insights into natural microbial strategies for coping with toxic compounds, enhancing our understanding of environmental adaptation and resilience. Through these applications, amauromine serves as a significant research tool in microbiology and environmental science.


Amauromine (CAS 88360-87-6) References

  1. Identification of a Potent and Selective Cannabinoid CB1 Receptor Antagonist from Auxarthron reticulatum.  |  Elsebai, MF., et al. 2011. ACS Med Chem Lett. 2: 866-9. PMID: 24900275
  2. GPR18 Inhibiting Amauromine and the Novel Triterpene Glycoside Auxarthonoside from the Sponge-Derived Fungus Auxarthron reticulatum.  |  Nazir, M., et al. 2015. Planta Med. 81: 1141-5. PMID: 26287693
  3. Diastereodivergent Reverse Prenylation of Indole and Tryptophan Derivatives: Total Synthesis of Amauromine, Novoamauromine, and epi-Amauromine.  |  Müller, JM. and Stark, CB. 2016. Angew Chem Int Ed Engl. 55: 4798-802. PMID: 26969898
  4. Anti-Cryptococcus Phenalenones and Cyclic Tetrapeptides from Auxarthron pseudauxarthron.  |  Li, Y., et al. 2017. J Nat Prod. 80: 2101-2109. PMID: 28657331
  5. Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?  |  Morales, P., et al. 2020. J Med Chem. 63: 14216-14227. PMID: 32914978
  6. Comprehensive Overview on the Chemistry and Biological Activities of Selected Alkaloid Producing Marine-Derived Fungi as a Valuable Reservoir of Drug Entities.  |  Youssef, FS. and Simal-Gandara, J. 2021. Biomedicines. 9: PMID: 33925060
  7. Formation of Pyrroloindolines via the Alkylation of Tryptamines with Trichloroacetimidates.  |  Joshi, BD. and Chisholm, JD. 2021. Tetrahedron Lett. 77: PMID: 34334833
  8. Neutral CB1 Receptor Antagonists as Pharmacotherapies for Substance Use Disorders: Rationale, Evidence, and Challenge.  |  Soler-Cedeno, O. and Xi, ZX. 2022. Cells. 11: PMID: 36291128
  9. Docking and Molecular Dynamic Investigations of Phenylspirodrimanes as Cannabinoid Receptor-2 Agonists.  |  Omar, AM., et al. 2022. Molecules. 28: PMID: 36615238
  10. OMICS and Other Advanced Technologies in Mycological Applications.  |  Wijayawardene, NN., et al. 2023. J Fungi (Basel). 9: PMID: 37367624

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Amauromine, 1 mg

sc-391052
1 mg
$180.00