AM3102 (CAS 213182-22-0)
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Oleoyl ethanolamide (OEA) is an endogenous agonist for proliferator-activated receptor α (PPARα) that promotes lipolysis, suppresses food intake, and reduces weight gain in rodents. The biological effects of OEA are terminated by N-acylethanolamine-hydrolyzing acid amidase and fatty-acid amide hydrolase. AM3102 is an OEA analog that stimulates PPARα transcriptional activity with an EC50 value of 100 nM and prolongs feeding latency in rodents with an ED50 value of 2.4 mg/kg (1). It is resistant to enzymatic hydrolysis and is as potent as OEA in reducing food intake in free-feeding rats and enhancing transcriptional activity of PPARα (1,2). AM3102 demonstrates weak affinity for the peripheral cannabinoid (CB2) and central cannabinoid (CB1) receptors with Ki values of 26 and 33 µM, respectively (3).
AM3102 (CAS 213182-22-0) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AM3102, 5 mg | sc-223774 | 5 mg | $53.00 | |||
AM3102, 10 mg | sc-223774A | 10 mg | $99.00 |