Date published: 2025-12-1

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AM 92016 hydrochloride (CAS 178894-81-0)

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Application:
AM 92016 hydrochloride is a specific blocker of the time dependent delayed rectifier potassium current
CAS Number:
178894-81-0
Purity:
≥98%
Molecular Weight:
483.84
Molecular Formula:
C19H24Cl2N2O4S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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AM 92016 hydrochloride is a compound that is of interest in neuroscience and biochemical research, particularly in the study of neurotransmitter systems. It acts as a ligand for certain serotonin receptors, which makes it useful for probing the function of these receptors in the central nervous system. Research involving AM 92016 hydrochloride typically focuses on its binding affinity and selectivity, providing insights into the role of serotonergic signaling in behavioral processes. Investigations using this compound help to characterize the profile of serotonin receptor subtypes and can contribute to the understanding of their physiological and pathophysiological roles. Additionally, AM 92016 hydrochloride is used to study the effects of receptor modulation on neuronal circuits.


AM 92016 hydrochloride (CAS 178894-81-0) References

  1. Actions and mechanisms of action of novel analogues of sotalol on guinea-pig and rabbit ventricular cells.  |  Connors, SP., et al. 1992. Br J Pharmacol. 106: 958-65. PMID: 1393293
  2. Tetraethylammonium exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures.  |  Katsuki, H., et al. 2005. Eur J Pharmacol. 508: 85-91. PMID: 15680257
  3. Role of SHP-1, Kv.1.2, and cGMP in nitric oxide-induced ERK1/2 MAP kinase dephosphorylation in rat vascular smooth muscle cells.  |  Palen, DI., et al. 2005. Cardiovasc Res. 68: 268-77. PMID: 15967421
  4. A whole-genome RNAi screen uncovers a novel role for human potassium channels in cell killing by the parasite Entamoeba histolytica.  |  Marie, C., et al. 2015. Sci Rep. 5: 13613. PMID: 26346926
  5. A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.  |  Ciarlo, C., et al. 2017. Elife. 6: PMID: 28832322
  6. The in-vivo cardiovascular effects of a putative class III anti-arrhythmic drug, AM 92016.  |  Hagerty, MJ., et al. 1996. J Pharm Pharmacol. 48: 417-21. PMID: 8794994

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

AM 92016 hydrochloride, 10 mg

sc-203506
10 mg
$230.00

AM 92016 hydrochloride, 50 mg

sc-203506A
50 mg
$1148.00