Molecular structure of AM-630, CAS Number: 164178-33-0
AM-630 (CAS 164178-33-0)
See product citations (8)
Alternate Names:
6-Iodopravodoline
Application:
AM-630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors
CAS Number:
164178-33-0
Purity:
≥98%
Molecular Weight:
504.40
Molecular Formula:
C23H25IN2O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AM-630 is a selective CB2 receptor antagonist that binds to CB1 and CB2 receptors with Ki values of 5.2 muM and 31.2 nM, respectively. AM630 may act to display 165-fold selectivity over CB1 receptors and behave as a weak partial/inverse agonist at CB1 receptors. AM-630 acts as an inverse agonist on cloned human CB1 receptors.
AM-630 (CAS 164178-33-0) References
- Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656, and AM630. | Ross, RA., et al. 1999. Br J Pharmacol. 126: 665-72. PMID: 10188977
- CB2 cannabinoid receptor-mediated peripheral antinociception. | Malan, PT., et al. 2001. Pain. 93: 239-245. PMID: 11514083
- Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test. | Yoon, MH. and Choi, JI. 2003. Anesthesiology. 99: 701-7. PMID: 12960556
- Characterization of rat liver microsomal metabolites of AM-630, a potent cannabinoid receptor antagonist, by high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. | Zhang, Q., et al. 2004. J Mass Spectrom. 39: 672-81. PMID: 15236306
- Keratoglobus lesions in the eyes of rearing broiler breeders. | Landman, WJ., et al. 1998. Avian Pathol. 27: 256-62. PMID: 18483995
- Development of a potent inhibitor of 2-arachidonoylglycerol hydrolysis with antinociceptive activity in vivo. | Bisogno, T., et al. 2009. Biochim Biophys Acta. 1791: 53-60. PMID: 19027877
- Beneficial effects of cannabinoid receptor type 2 (CB2R) in injured skeletal muscle post-contusion. | Yu, T., et al. 2015. Histol Histopathol. 30: 737-49. PMID: 25588471
- JWH-133, a Selective Cannabinoid CB₂ Receptor Agonist, Exerts Toxic Effects on Neuroblastoma SH-SY5Y Cells. | Wojcieszak, J., et al. 2016. J Mol Neurosci. 58: 441-5. PMID: 26842917
- In vivo Bidirectional Modulation of Cannabinoid on the Activity of Globus Pallidus in Rats. | Yu, JJ., et al. 2021. Neuroscience. 468: 123-138. PMID: 34129911
- Inhibition of Nociception in a Preclinical Episodic Migraine Model by Dietary Supplementation of Grape Seed Extract Involves Activation of Endocannabinoid Receptors. | Woodman, SE., et al. 2022. Front Pain Res (Lausanne). 3: 809352. PMID: 35295808
- Transcription Profile and Pathway Analysis of the Endocannabinoid Receptor Inverse Agonist AM630 in the Core and Infiltrative Boundary of Human Glioblastoma Cells. | Williams, G., et al. 2022. Molecules. 27: PMID: 35408449
- AM630 antagonism of cannabinoid-stimulated [35S]GTP gamma S binding in the mouse brain. | Hosohata, Y., et al. 1997. Eur J Pharmacol. 321: R1-3. PMID: 9083796
- AM630 is a competitive cannabinoid receptor antagonist in the guinea pig brain. | Hosohata, K., et al. 1997. Life Sci. 61: PL115-8. PMID: 9284087
Inhibitor of:
CB2, CBS, CNR1, CNR2, CNRIP1, Olfr49, Olfr490, and Vmn2r29.Activator of:
CNR2, and GPR10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AM-630, 5 mg | sc-200365B | 5 mg | $78.00 | |||
AM-630, 10 mg | sc-200365 | 10 mg | $166.00 | |||
AM-630, 50 mg | sc-200365A | 50 mg | $634.00 | |||
AM-630, 100 mg | sc-200365C | 100 mg | $869.00 |