Molecular structure of AM 404, CAS Number: 183718-77-6
AM 404 (CAS 183718-77-6)
Alternate Names:
N-(4-Hydroxyphenyl)-arachidonylamide
Application:
AM 404 is binds weakly to CB1 and CB2 cannabinoid receptors
CAS Number:
183718-77-6
Purity:
≥98%
Molecular Weight:
395.58
Molecular Formula:
C26H37NO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
Safety Information
SDS & Certificate of Analysis
A metabolite of the well-known analgesic Paracetamol.
AM 404 (CAS 183718-77-6) References
- Elevated circulating levels of anandamide after administration of the transport inhibitor, AM404. | Giuffrida, A., et al. 2000. Eur J Pharmacol. 408: 161-8. PMID: 11080522
- Prenatal elevation of endocannabinoids corrects the unbalance between dopamine systems and reduces activity in the Naples High Excitability rats. | Viggiano, D., et al. 2003. Neurosci Biobehav Rev. 27: 129-39. PMID: 12732229
- Role of TRPV1 and cannabinoid CB1 receptors in AM 404-evoked hypothermia in rats. | Rawls, SM., et al. 2006. Pharmacol Biochem Behav. 83: 508-16. PMID: 16647109
- Effects of cannabinoids on the anxiety-like response in mice. | Rutkowska, M., et al. 2006. Pharmacol Rep. 58: 200-6. PMID: 16702621
- 5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats. | Braida, D., et al. 2007. Eur J Pharmacol. 555: 156-63. PMID: 17116299
- Acute ethanol suppresses glutamatergic neurotransmission through endocannabinoids in hippocampal neurons. | Basavarajappa, BS., et al. 2008. J Neurochem. 107: 1001-13. PMID: 18796007
- Extinction of avoidance behavior by safety learning depends on endocannabinoid signaling in the hippocampus. | Micale, V., et al. 2017. J Psychiatr Res. 90: 46-59. PMID: 28222356
- Acetaminophen Metabolite N-Acylphenolamine Induces Analgesia via Transient Receptor Potential Vanilloid 1 Receptors Expressed on the Primary Afferent Terminals of C-fibers in the Spinal Dorsal Horn. | Ohashi, N., et al. 2017. Anesthesiology. 127: 355-371. PMID: 28542001
- TRPV1 mediates the anticonvulsant effects of acetaminophen in mice. | Suemaru, K., et al. 2018. Epilepsy Res. 145: 153-159. PMID: 30007240
- Functional role of high-affinity anandamide transport, as revealed by selective inhibition. | Beltramo, M., et al. 1997. Science. 277: 1094-7. PMID: 9262477
Inhibitor of:
CB1, CB2, and FAAH.Activator of:
TRPV1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AM 404, 10 mg | sc-207275 | 10 mg | $118.00 |