Molecular structure of ALX 5407 hydrochloride, CAS Number: 200006-08-2
ALX 5407 hydrochloride (CAS 200006-08-2)
Alternate Names:
NFPS; N-[(3R)-3-([1,1′-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride
Application:
ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1
CAS Number:
200006-08-2
Purity:
≥99%
Molecular Weight:
429.92
Molecular Formula:
C24H24FNO3•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
ALX 5407 hydrochloride is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH). ALX 5407 is responsible for the degradation of endocannabinoids, which are lipid signaling molecules involved in various physiological processes. By inhibiting FAAH, ALX 5407 hydrochloride increases the levels of endocannabinoids, leading to modulation of pain, inflammation, and other neurological functions.
ALX 5407 hydrochloride (CAS 200006-08-2) References
- Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes. | Herdon, HJ., et al. 2001. Neuropharmacology. 41: 88-96. PMID: 11445189
- ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. | Atkinson, BN., et al. 2001. Mol Pharmacol. 60: 1414-20. PMID: 11723250
- N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. | Aubrey, KR. and Vandenberg, RJ. 2001. Br J Pharmacol. 134: 1429-36. PMID: 11724748
- Mechanisms of [(3)H]glycine release from mouse spinal cord synaptosomes selectively labeled through GLYT2 transporters. | Luccini, E. and Raiteri, L. 2007. J Neurochem. 103: 2439-48. PMID: 17944872
- Frequency-dependent glycinergic inhibition modulates plasticity in hippocampus. | Keck, T., et al. 2008. J Neurosci. 28: 7359-69. PMID: 18632940
- Impaired glycinergic synaptic transmission and enhanced inflammatory pain in mice with reduced expression of vesicular GABA transporter (VGAT). | Yamada, MH., et al. 2012. Mol Pharmacol. 81: 610-9. PMID: 22275517
- Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). | Chue, P. 2013. Curr Pharm Des. 19: 1311-20. PMID: 23194655
- Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor. | Gardella, E., et al. 2013. Neurochem Int. 62: 360-6. PMID: 23411412
- A new function for glycine GlyT2 transporters: Stimulation of γ-aminobutyric acid release from cerebellar nerve terminals through GAT1 transporter reversal and Ca(2+)-dependent anion channels. | Milanese, M., et al. 2014. J Neurosci Res. 92: 398-408. PMID: 24273061
- Synthesis and Biological Evaluation of N-((1-(4-(Sulfonyl)piperazin-1-yl)cycloalkyl)methyl)benzamide Inhibitors of Glycine Transporter-1. | Cioffi, CL., et al. 2016. J Med Chem. 59: 8473-94. PMID: 27559615
- Differential regulation of NMDA receptors by d-serine and glycine in mammalian spinal locomotor networks. | Acton, D. and Miles, GB. 2017. J Neurophysiol. 117: 1877-1893. PMID: 28202572
- Glycine Transporter-1 and glycine receptor mediate the antioxidant effect of glycine in diabetic rat islets and INS-1 cells. | Chen, L., et al. 2018. Free Radic Biol Med. 123: 53-61. PMID: 29753073
- Control of amino acid transport into Chinese hamster ovary cells. | Geoghegan, D., et al. 2018. Biotechnol Bioeng. 115: 2908-2929. PMID: 29987891
- Subsaturation of the N-methyl-D-aspartate receptor glycine site allows the regulation of bursting activity in juvenile rat nigral dopamine neurons. | Destreel, G., et al. 2019. Eur J Neurosci. 50: 3454-3471. PMID: 31206829
Inhibitor of:
GlyT1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ALX 5407 hydrochloride, 10 mg | sc-361102 | 10 mg | $220.00 | |||
ALX 5407 hydrochloride, 50 mg | sc-361102A | 50 mg | $900.00 |