Date published: 2026-4-1

1-800-457-3801

SCBT Portrait Logo
Seach Input

Alsterpaullone (CAS 237430-03-4)

5.0(1)
Write a reviewAsk a question

See product citations (2)

Alternate Names:
9-Nitropaullone
Application:
Alsterpaullone is a potent ATP-competitive and cell cycle cylin-dependent kinase inhibitor
CAS Number:
237430-03-4
Purity:
>95%
Molecular Weight:
293.28
Molecular Formula:
C16H11N3O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

QUICK LINKS

Alsterpaullone is a potent ATP-competitive and cell cycle cyclin-dependent kinase inhibitor, that is reported to be the most active Paullone (sc-208152). The paullones belong to a family of benzazepinones, and are described to highly inhibit neuronal CDK5/p25 and glycogen synthase kinase-3beta (GSK-3beta). Studies report that Alsterpaullone activates caspase-9 and enhances apoptosis in Jurkat cells, inhibits CDK5/p25-dependent phosphorylation of DARPP-32 in in vitro mouse striatum slices, and blocks the phosphorylation of Tau by GSK-3beta.


Alsterpaullone (CAS 237430-03-4) References

  1. Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.  |  Leost, M., et al. 2000. Eur J Biochem. 267: 5983-94. PMID: 10998059
  2. Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential.  |  Lahusen, T., et al. 2003. Mol Carcinog. 36: 183-94. PMID: 12669310
  3. Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.  |  Beaulieu, JM., et al. 2004. Proc Natl Acad Sci U S A. 101: 5099-104. PMID: 15044694
  4. Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway.  |  Chirnomas, D., et al. 2006. Mol Cancer Ther. 5: 952-61. PMID: 16648566
  5. Proliferative and androgenic effects of indirubin derivatives in LNCaP human prostate cancer cells at sub-apoptotic concentrations.  |  Rivest, P., et al. 2011. Chem Biol Interact. 189: 177-85. PMID: 21111724
  6. In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains.  |  Moro, E., et al. 2012. Dev Biol. 366: 327-40. PMID: 22546689
  7. Ectopic activation of the canonical wnt signaling pathway affects ectodermal patterning along the primary axis during larval development in the anthozoan Nematostella vectensis.  |  Marlow, H., et al. 2013. Dev Biol. 380: 324-34. PMID: 23722001
  8. Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma.  |  Faria, CC., et al. 2015. Oncotarget. 6: 21718-29. PMID: 26061748
  9. The genetic program for cartilage development has deep homology within Bilateria.  |  Tarazona, OA., et al. 2016. Nature. 533: 86-9. PMID: 27111511
  10. High-content screening assay-based discovery of paullones as novel podocyte-protective agents.  |  Lee, HW., et al. 2018. Am J Physiol Renal Physiol. 314: F280-F292. PMID: 29046299
  11. Glycogen Synthase Kinase 3β Inhibitor Delivered by Chitosan Nanocapsules Promotes Safe, Fast, and Efficient Activation of Wnt Signaling In Vivo.  |  Ambrosone, A., et al. 2020. ACS Biomater Sci Eng. 6: 2893-2903. PMID: 33463287
  12. Computational Drug Repurposing for Alzheimer's Disease Using Risk Genes From GWAS and Single-Cell RNA Sequencing Studies.  |  Xu, Y., et al. 2021. Front Pharmacol. 12: 617537. PMID: 34276354
  13. Histamine induces nuclear factor of activated T cell-mediated transcription and cyclosporin A-sensitive interleukin-8 mRNA expression in human umbilical vein endothelial cells.  |  Boss, V., et al. 1998. Mol Pharmacol. 54: 264-72. PMID: 9687567

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alsterpaullone, 1 mg

sc-202453
1 mg
$68.00

Alsterpaullone, 5 mg

sc-202453A
5 mg
$312.00