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Alrestatin is an AKR (aldose reductase) inhibitor, which attaches molecules to the active site of the NADP+/enzyme complex in a stacked formation. Studies conducted on diabetic models suggest that Alrestatin inhibits the mean basal insulin level. Alrestatin suppresses the accumulation of cAMP which is induced by prostaglandin E2. Theses studies indicate that Alrestatin can be essential in studying variations in hormone release caused by cAMP accumulation. Alternatively, Alrestatin has been shown to inhibit the formation of cataracts in lenses via the sorbitol pathway. In rats Alrestatin inhibits gastric juice production in the pylorus-ligated rat when it is administered intraperitoneally.
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