Alrestatin CAS: 51411-04-2
MF: C14H9NO4
MW: 255.2
An AKR inhibitor.

Alrestatin (CAS 51411-04-2)

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Application: An AKR inhibitor
CAS Number: 51411-04-2
Purity: ≥99%
Molecular Weight: 255.2
Molecular Formula: C14H9NO4
* Refer to Certificate of Analysis for lot specific data (including water content).
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Alrestatin is an AKR (aldose reductase) inhibitor, which attaches molecules to the active site of the NADP+/enzyme complex in a stacked formation. Studies conducted on diabetic models suggest that Alrestatin inhibits the mean basal insulin level. Alrestatin suppresses the accumulation of cAMP which is induced by prostaglandin E2. Theses studies indicate that Alrestatin can be essential in studying variations in hormone release caused by cAMP accumulation. Alternatively, Alrestatin has been shown to inhibit the formation of cataracts in lenses via the sorbitol pathway. In rats Alrestatin inhibits gastric juice production in the pylorus-ligated rat when it is administered intraperitoneally.


References

1. Lippmann, W., et al. 1978. Digestion. 18: 35-44. PMID: 103765
2. Lippmann, W. 1978. Experientia. 34: 441-443. PMID: 205429
3. Chylack, L.T., et al. 1979. Ophthalmology. 86: 1579-1585. PMID: 121768
4. Distiller, L.A., et al. 1981. J. Endocrinol. Invest. 4: 115-117. PMID: 6787107
5. Humber, L.G. 1987. Prog Med Chem. 24: 299-343. PMID: 3144023
6. Ehrig, T., et al. 1994. Biochemistry. 33: 7157-7165. PMID: 8003482
7. Lavrentyev, E.N., et al. 2007. Circ. Res. 101: 455-464. PMID: 17626897

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Store at room temperature
Melting Point :
262-265° C
Boiling Point :
512.73° C at 760 mmHg (Predicted)
Density :
1.51 g/cm3 (Predicted)
Refractive Index :
n20D 1.72 (Predicted)
IC50 :
aldose reductase: IC50 = 148 µM
pK Values :
pKa: 3.61 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
RTECS :
DE4080500
PubChem CID :
2120
SMILES :
C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)CC(=O)O

Download SDS (MSDS)

Certificate of Analysis

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