Date published: 2026-6-28

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Alphadolone (CAS 14107-37-0)

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Alternate Names:
(3α,5α)-3,21-Dihydroxypregnane-11,20-dione; 3α,21-Dihydroxy-5α-pregnane-11,20-dione; 3α,21-Dihydroxy-5α-pregnane-11,20-dione
CAS Number:
14107-37-0
Molecular Weight:
348.48
Molecular Formula:
C21H32O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Alphadolone is a compound used for neuroscientific research due to its relation to the central nervous system. It acts on GABAA receptors as a positive allosteric modulator, which are pivotal in mediating inhibitory neurotransmission in the brain. This modulation is key to understanding the mechanisms of synaptic plasticity and neuronal inhibition. Alphadolone is often utilized to dissect the role of GABAergic transmission in behavior and to model the effects of substances that enhance inhibitory signaling in the brain. Its impact on the GABAergic system also provides a valuable framework for researching the neurobiological underpinnings of stress responses and various neurological conditions.


Alphadolone (CAS 14107-37-0) References

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  2. Antinociceptive properties of neurosteroids III: experiments with alphadolone given intravenously, intraperitoneally, and intragastrically.  |  Nadeson, R. and Goodchild, CS. 2001. Br J Anaesth. 86: 704-8. PMID: 11575348
  3. Preliminary studies of the actions of alphaxalone and alphadolone in the pig.  |  Cox, JE., et al. Vet Rec. 97: 497-8. PMID: 1202746
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  13. Seizure duration in unilateral electroconvulsive therapy. A comparison of the anaesthetic agents etomidate and Althesin with methohexitone.  |  Gran, L., et al. 1984. Acta Psychiatr Scand. 69: 472-83. PMID: 6741597
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  15. The electrocardiogram of the cheetah (Acinonyx jubatus).  |  Button, C., et al. 1981. J S Afr Vet Assoc. 52: 233-5. PMID: 7310794

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Alphadolone, 5 mg

sc-481719
5 mg
$453.00