α_1D-AR Antibody (F-10): sc-390884

α1D-AR Antibody (F-10) is a mouse monoclonal IgM antibody that detects α1D-AR of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-α1D-AR antibody (F-10) is available as the non-conjugated form. The alpha 1D-adrenergic receptor (α1D-AR) plays a crucial role in sympathetic regulation of systemic blood pressure through coupling to Gq/11, which mediates vasoconstriction. α1D-AR (F-10) antibody recognizes this receptor predominantly in tissues such as the prostate and aorta, where α1D-AR contributes to modulation of vascular tone and blood flow. Notably, α1D-AR can form hetero-oligomers with α1B receptors, which may influence receptor signaling and functional outcomes in various physiological contexts. Alternative splicing generates multiple isoforms of α1D-AR, each with distinct C-termini, leading to diverse activation patterns essential for fine-tuning adrenergic responses. Understanding the functional implications of α1D-AR interactions and expression profile is vital for elucidating its role in cardiovascular health and disease, making anti-α1D-AR antibody (F-10) an invaluable tool for researchers studying adrenergic signaling pathways.

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α_1D-AR Antibody (F-10) References:

1. The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.  |  Tanoue, A., et al. 2002. J Clin Invest. 109: 765-75. PMID: 11901185
2. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors.  |  Hague, C., et al. 2004. J Biol Chem. 279: 15541-9. PMID: 14736874
3. Functional expression of the human serotonin 5-HT1A receptor in Escherichia coli. Ligand binding properties and interaction with recombinant G protein alpha-subunits.  |  Bertin, B., et al. 1992. J Biol Chem. 267: 8200-6. PMID: 1533220
4. Alpha1-adrenoreceptor in human hippocampus: binding and receptor subtype mRNA expression.  |  Szot, P., et al. 2005. Brain Res Mol Brain Res. 139: 367-71. PMID: 16039007
5. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction.  |  Chen, Z., et al. 2006. J Biol Chem. 281: 12414-20. PMID: 16533813
6. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase.  |  Levy, FO., et al. 1992. FEBS Lett. 296: 201-6. PMID: 1733778
7. Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.  |  Hausdorff, WP., et al. 1990. Symp Soc Exp Biol. 44: 225-40. PMID: 1983369
8. Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.  |  Cotecchia, S., et al. 1990. J Biol Chem. 265: 63-9. PMID: 2152928
9. The three α1-adrenoceptor subtypes show different spatio-temporal mechanisms of internalization and ERK1/2 phosphorylation.  |  Perez-Aso, M., et al. 2013. Biochim Biophys Acta. 1833: 2322-33. PMID: 23797059
10. The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.  |  Barak, LS., et al. 1995. Biochemistry. 34: 15407-14. PMID: 7492540
11. Phosphoinositide system-linked serotonin receptor subtypes and their pharmacological properties and clinical correlates.  |  Pandey, SC., et al. 1995. J Psychiatry Neurosci. 20: 215-25. PMID: 7786883
12. Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.  |  Weinberg, DH., et al. 1994. Biochem Biophys Res Commun. 201: 1296-304. PMID: 8024574

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-α_1D-AR Antibody (F-10) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-α_1D-AR Antibody (F-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

α_1D-AR Antibody (F-10) Specifications

Alternate Product Name: α1D-AR

Product Clone Name: F-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 542-561

Epitope Target: α1D-AR

Epitope Species: rat

Product Reactivity/Detection: α_1D-AR

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for α_1D-AR Antibody (F-10): P: Blocking Peptide